Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro

Jang Hoon Sung, Sung Joon Lee, Kwan Hwa Park, Tae Wha Moon

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. Ki values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 μM, respectively.

Original languageEnglish
Pages (from-to)428-432
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number2
Publication statusPublished - 2004 Feb
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant from the National Research Laboratory Program funded by the Ministry of Science and Technology of the Republic of Korea.


  • Cholesterol
  • Genistein
  • HMG-CoA reductase
  • Isoflavone
  • Soybean

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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