Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

Nguyen Tuan Hiep, Jaeyoung Kwon, Dong Woo Kim, Bang Yeon Hwang, Hak Ju Lee, Woongchon Mar, Dongho Lee

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 μM.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
Publication statusPublished - 2015 Mar

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea University , the Korea Forest Research Institute , and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2013R1A1A2008111).

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.


  • 6-OHDA
  • Cudrania tricuspidata
  • Human neuroblastoma SH-SY5Y
  • Isoflavones
  • Moraceae
  • Neuroprotection
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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