Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo, Hoon Kim, Hyeon Son Choi, Seung Su Lee, Myun Ho Bang, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Original languageEnglish
Pages (from-to)1833-1842
Number of pages10
JournalFood Science and Biotechnology
Issue number6
Publication statusPublished - 2018 Dec 1


  • GABA type A-benzodiazepine receptor
  • Glyceryl monolinoleate
  • Insomnia
  • Polygonatum sibiricum
  • Sleep

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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