Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo; Hoon Kim; Hyeon Son Choi; Seung Su Lee; Myun Ho Bang; Hyung Joo Suh

doi:10.1007/s10068-018-0431-0

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo, Hoon Kim, Hyeon Son Choi, Seung Su Lee, Myun Ho Bang, Hyung Joo Suh

School of Biosystem and Biomedical Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABA_A-BDZ receptor. The chemical structure of the pure compound was determined by the ¹H and ¹³C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [³H]-flumazenil binding to GABA_A-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Original language	English
Pages (from-to)	1833-1842
Number of pages	10
Journal	Food Science and Biotechnology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1007/s10068-018-0431-0
Publication status	Published - 2018 Dec 1

Keywords

GABA type A-benzodiazepine receptor
Glyceryl monolinoleate
Insomnia
Polygonatum sibiricum
Sleep

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-018-0431-0

Cite this

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title = "Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome",

abstract = "The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.",

keywords = "GABA type A-benzodiazepine receptor, Glyceryl monolinoleate, Insomnia, Polygonatum sibiricum, Sleep",

author = "Kyungae Jo and Hoon Kim and Choi, {Hyeon Son} and Lee, {Seung Su} and Bang, {Myun Ho} and Suh, {Hyung Joo}",

note = "Funding Information: This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). The authors declare no conflict of interest. Funding Information: Acknowledgements This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). Publisher Copyright: {\textcopyright} 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.",

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AU - Jo, Kyungae

AU - Kim, Hoon

AU - Choi, Hyeon Son

AU - Lee, Seung Su

AU - Bang, Myun Ho

AU - Suh, Hyung Joo

N1 - Funding Information: This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). The authors declare no conflict of interest. Funding Information: Acknowledgements This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). Publisher Copyright: © 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

AB - The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

KW - GABA type A-benzodiazepine receptor

KW - Glyceryl monolinoleate

KW - Insomnia

KW - Polygonatum sibiricum

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Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Abstract

Keywords

ASJC Scopus subject areas

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