Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo; Hoon Kim; Hyeon Son Choi; Seung Su Lee; Myun Ho Bang; Hyung Joo Suh

doi:10.1007/s10068-018-0431-0

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kyungae Jo
, Hoon Kim
, Hyeon Son Choi
, Seung Su Lee
, Myun Ho Bang
, Hyung Joo Suh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABA_A-BDZ receptor. The chemical structure of the pure compound was determined by the ¹H and ¹³C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [³H]-flumazenil binding to GABA_A-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

Original language	English
Pages (from-to)	1833-1842
Number of pages	10
Journal	Food Science and Biotechnology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1007/s10068-018-0431-0
Publication status	Published - 2018 Dec 1

Bibliographical note

Funding Information:
This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). The authors declare no conflict of interest.

Funding Information:
Acknowledgements This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020).

Publisher Copyright:
© 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.

Keywords

GABA type A-benzodiazepine receptor
Glyceryl monolinoleate
Insomnia
Polygonatum sibiricum
Sleep

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-018-0431-0

Cite this

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title = "Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome",

abstract = "The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38\% and a decrease of rapid eye movement by 31\% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.",

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author = "Kyungae Jo and Hoon Kim and Choi, \{Hyeon Son\} and Lee, \{Seung Su\} and Bang, \{Myun Ho\} and Suh, \{Hyung Joo\}",

note = "Funding Information: This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). The authors declare no conflict of interest. Funding Information: Acknowledgements This research was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through the High Value-Added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116004-02-2-HD020). Publisher Copyright: {\textcopyright} 2018, The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature.",

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AU - Bang, Myun Ho

AU - Suh, Hyung Joo

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PY - 2018/12/1

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N2 - The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

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ER -

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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