TY - GEN
T1 - Joint estimation of multiple clinical variables of neurological diseases from imaging patterns
AU - Fan, Yong
AU - Kaufer, Daniel
AU - Shen, Dinggang
PY - 2010
Y1 - 2010
N2 - This paper presents a method to estimate multiple clinical variables associated with neurological pathologies from brain images, aiming to quantitatively evaluate continuous transition of neurological pathologies from the normal to diseased state. Built upon morphological measures derived from structural MR brain images, a Bayesian regression method is developed to jointly model multiple clinical variables for capturing their inherent correlations and suppressing noise. Coupled with a feature selection technique, the regression method is used to build a joint estimator of multiple clinical variables associated with Alzheimer's disease from structural MR brain images of elderly individuals. The cross-validation results demonstrate that the proposed method has superior performance over existing techniques.
AB - This paper presents a method to estimate multiple clinical variables associated with neurological pathologies from brain images, aiming to quantitatively evaluate continuous transition of neurological pathologies from the normal to diseased state. Built upon morphological measures derived from structural MR brain images, a Bayesian regression method is developed to jointly model multiple clinical variables for capturing their inherent correlations and suppressing noise. Coupled with a feature selection technique, the regression method is used to build a joint estimator of multiple clinical variables associated with Alzheimer's disease from structural MR brain images of elderly individuals. The cross-validation results demonstrate that the proposed method has superior performance over existing techniques.
KW - ADAS-Cog
KW - Alzheimer's disease
KW - Bayesian regression
KW - MMSE
KW - Structural MR brain image
UR - http://www.scopus.com/inward/record.url?scp=77955198893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955198893&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2010.5490120
DO - 10.1109/ISBI.2010.5490120
M3 - Conference contribution
AN - SCOPUS:77955198893
SN - 9781424441266
T3 - 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings
SP - 852
EP - 855
BT - 2010 7th IEEE International Symposium on Biomedical Imaging
T2 - 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
Y2 - 14 April 2010 through 17 April 2010
ER -