Joint feature-sample selection and robust classification for Parkinson’s disease diagnosis

Ehsan Adeli-Mosabbeb, Chong Yaw Wee, Le An, Feng Shi, Dinggang Shen

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    4 Citations (Scopus)

    Abstract

    Parkinson’s disease (PD) is an overwhelming neurodegenerative disorder caused by deterioration of a neurotransmitter, known as dopamine. Lack of this chemical messenger in the brain impairs several brain regions and yields to various movement and non-motor symptoms. The incidence of PD is considered to be doubled in the next two decades and this urges more researches on its early diagnosis and treatment. In this paper, we propose an approach to diagnose PD using magnetic resonance imaging (MRI) data. We first introduce a joint feature-sample selection method to select the optimal subset of samples and features for a reliable training process. This procedure selects the most discriminative features and discards poor sample (outliers). Then, a robust classification framework is proposed that can simultaneously de-noise the selected subset of features and samples, and learn a classification model. Our model can further de-noise the test samples based on the cleaned training data. Experimental results on both synthetic and a publicly available PD dataset show promising results.

    Original languageEnglish
    Title of host publicationMedical Computer Vision
    Subtitle of host publicationAlgorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers
    EditorsMichael Kelm, Henning Müller, Bjoern Menze, Shaoting Zhang, Dimitris Metaxas, Georg Langs, Albert Montillo, Weidong Cai
    PublisherSpringer Verlag
    Pages127-136
    Number of pages10
    ISBN (Print)9783319420158
    DOIs
    Publication statusPublished - 2016
    EventInternational Workshop on Medical Image Computing for Computer Assisted Intervention, 2015 MICCAI - Germany, Germany
    Duration: 2015 Oct 92015 Oct 9

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume9601 LNCS
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    OtherInternational Workshop on Medical Image Computing for Computer Assisted Intervention, 2015 MICCAI
    Country/TerritoryGermany
    CityGermany
    Period15/10/915/10/9

    Bibliographical note

    Publisher Copyright:
    © Springer International Publishing Switzerland 2016.

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • General Computer Science

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