Key Structural Elements for Cellular Uptake of Acinetobactin, a Major Siderophore of Acinetobacter baumannii

Woon Young Song, Dawa Jeong, Jimin Kim, Min Wook Lee, Man Hwan Oh, Hak Joong Kim

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Acinetobactin is a major siderophore utilized by the human pathogen Acinetobacter baumannii. The rapid acquisition of drug resistance by A. baumannii has garnered concern globally. Herein, acinetobactin and systematically generated analogues were prepared and characterized; the binding and cellular delivery of Fe(III) by the analogues were evaluated. This investigation not only led to the clarification of the physiologically relevant acinetobactin structure but also revealed several key structural elements for its functionality as a siderophore.

Original languageEnglish
Pages (from-to)500-503
Number of pages4
JournalOrganic Letters
Volume19
Issue number3
DOIs
Publication statusPublished - 2017 Feb 3

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant (Grant Nos. NRF-2012R1A1A1042665, NRF-2015R1D1A1A01056815 NRF20110020033, and NRF-2016R1C1B1016370). We also thank Ms. Hyun Hee Lee and Mr. Yunhwa Choi for their helpful assistance on the mass data collection and the hemolytic activity assay, respectively.

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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