Kidney toxicity induced by 13 weeks exposure to the fruiting body of Paecilomyces sinclairii in rats

Mihye Jeong, Young Won Kim, Jeong Ran Min, Min Kwon, Beom Suk Han, Jeong Gyu Kim, Sang Hee Jeong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Paecilomyces sinclairiis (PS) is known as a functional food or human health supplement. However concerns have been raised about its kidney toxicity. This study was performed to investigate the kidney toxicity of PS by 13 week-oral administration to rats. Blood urea nitrogen (BUN), serum creatinine, and kidney damage biomarkers including beta-2-microglobulin (β2m), glutathione S-transferase alpha (GST-a), kidney injury molecule 1 (KIM-1), tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), vascular endothelial growth factor (VEGF), calbindin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin were measured during or after the treatment of PS. BUN, creatinine and kidney damage biomarkers in serum were not changed by PS. However, kidney cell karyomegalyand tubular hypertrophy were observed dose-dependently with higher severity in males. KIM-1, TIMP-1 and osteopontin in kidney and urine were increased dose dependently in male or at the highest dose in female rats. Increased urinary osteopontin by PS was not recovered at 2 weeks of post-exposure in both genders. Cystatin C in kidney was decreased at all treatment groups but inversely increased in urine. The changes in kidney damage biomarkers were more remarkable in male than female rats. These data indicate that the PS may provoke renal cell damage and glomerular filtration dysfunction in rats withhistopathological lesions and change of kidney damage biomarkers in kidney or urine. Kidney and urinary KIM-1 and cystatin C were the most marked indicators, while kidney weight, BUN and creatinine and kidney damage biomarkers in serum were not influenced.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalToxicological Research
Issue number3
Publication statusPublished - 2012

Bibliographical note

Funding Information:
We thank the staffs at Fermilab and collaborating institutions, and acknowledge support from the DOE and NSF (USA); CEA and CNRS/IN2P3 (France); FASI, Rosatom and RFBR (Russia); CAPES, CNPq, FAPERJ, FAPESP and FUNDUNESP (Brazil); DAE and DST (India); Colciencias (Colombia); CONACyT (Mexico); KRF and KOSEF (South Korea); CONICET and UBACyT (Argentina); FOM (The Netherlands); PPARC (United Kingdom); MSMT (Czech Republic); CRC Program, CFI, NSERC and WestGrid Project (Canada); BMBF and DFG (Germany); SFI (Ireland); The Swedish Research Council (Sweden); Research Corporation; Alexander von Humboldt Foundation; and the Marie Curie Program.


  • Cystatin C
  • Kidney damage biomarkers
  • Kidney injury molecule 1
  • Kidney toxicity
  • Paecilomyces sinclairiis

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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