Kilovoltage radiotherapy for companion animals: Dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams

Jaehyeon Seo, Jaeman Son, Yeona Cho, Nohwon Park, Dong Wook Kim, Jinsung Kim, Myonggeun Yoon

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Radiotherapy for the treatment of cancer in companion animals is currently administered by using megavoltage X-ray machines. Because these machines are expensive, most animal hospitals do not perform radiotherapy. This study evaluated the ability of relatively inexpensive kilovoltage X-ray machines to treat companion animals. A simulation study based on a commercial treatment-planning system was performed for tumors of the brain (non-infectious meningoencephalitis), nasal cavity (malignant nasal tumors), forefoot (malignant muscular tumors), and abdomen (malignant intestinal tumors). The results of kilovoltage (300 kV and 450 kV) and megavoltage (6 MV) X-ray beams were compared. Whereas the 300 kV and 6 MV X-ray beams provided optimal radiation dose homogeneity and conformity, respectively, for brain tumors, the 6 MV X-rays provided optimal homogeneity and radiation conformity for nasal cavity, forefoot, and abdominal tumors. Although megavoltage X-ray beams provided better radiation dose distribution in most treated animals, the differences between megavoltage and kilovoltage X-ray beams were relatively small. The similar therapeutic effects of the kilovoltage and 6 MV X-ray beams suggest that kilovoltage X-ray beams may be effective alternatives to megavoltage X-ray beams in treating cancers in companion animals.

Original languageEnglish
Pages (from-to)550-556
Number of pages7
JournalJournal of Veterinary Science
Issue number4
Publication statusPublished - 2018

Bibliographical note

Funding Information:
This work was supported by the National Nuclear R&D Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (NRF-2015M2A2A7A02045273 and NRF-2017M2A2A7081416); and the Ministry of Science and ICT (NRF-2017M2A2A6A01071189), Republic of Korea.

Publisher Copyright:
© 2018 The Korean Society of Veterinary Science.


  • Companion animals
  • Radiation therapy
  • X-ray

ASJC Scopus subject areas

  • General Veterinary


Dive into the research topics of 'Kilovoltage radiotherapy for companion animals: Dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams'. Together they form a unique fingerprint.

Cite this