TY - JOUR
T1 - Knee osteoarthritis and menopausal hormone therapy in postmenopausal women
T2 - a nationwide cross-sectional study
AU - Jung, Jae Hyun
AU - Bang, Cho Hee
AU - Song, Gwan Gyu
AU - Kim, Cholhee
AU - Kim, Jae Hoon
AU - Choi, Sungjae
PY - 2018/12/21
Y1 - 2018/12/21
N2 - OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.
AB - OBJECTIVE: The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data. METHODS: Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings. RESULTS: In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group. CONCLUSIONS: The prevalence of knee OA was lower in participants with MHT than in those without MHT.
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U2 - 10.1097/GME.0000000000001280
DO - 10.1097/GME.0000000000001280
M3 - Article
C2 - 30586007
AN - SCOPUS:85066923940
SN - 1072-3714
VL - 26
SP - 598
EP - 602
JO - Menopause (New York, N.Y.)
JF - Menopause (New York, N.Y.)
IS - 6
ER -