Korean red ginseng extract increases apoptosis by activation of the noxa pathway in colorectal cancer

Yoon A. Jeong, Bo Ram Kim, Dae Young Kim, Soyeon Jeong, Yoo Jin Na, Jung Lim Kim, Hye Kyeong Yun, Bu Gyeom Kim, Seong Hye Park, Min Jee Jo, Sun Il Lee, Byung Cheol Han, Dae Hee Lee, Sang Cheul Oh

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells. Methods: In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells. Results: We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells. Conclusion: Our results show that KRG can be used as a possible anticancer drug for patients with CRC.

Original languageEnglish
Article number2026
JournalNutrients
Volume11
Issue number9
DOIs
Publication statusPublished - 2019 Sept

Bibliographical note

Funding Information:
This work was supported by the Korea Ginseng Corporation Q1726001 and a Korea University Grant. Funding: This work was supported by the Korea Ginseng Corporation Q1726001 and a Korea University Grant. Acknowledgments: Korean Red Ginseng power was kindly provided by the Korea Ginseng Corporation. We thank Korea Ginseng Corporation for its support of Korean Red Ginseng powder.

Funding Information:
Author Contributions: Y.A.J. and B.R.K. conceived and designed the study, collected and assembled the data, Author Contributions: Y.A.J. and B.R.K. conceived and designed the study, collected and assembled the data, analyzed and interpreted the data, and wrote the manuscript. M.J.J., Y.J.N., H.K.Y., D.Y.K. and B.G.K. conceived analyzed and interpreted the data, and wrote the manuscript. M.J.J., Y.J.N., H.K.Y., D.Y.K. and B.G.K. conceived and designed the study and analyzed and interpreted the data. S.J., J.L.K. and S.H.P conceived and designed the stsutuddy.yB. H.-C.-.BH.C.,.D, D.-.H-H.L.L.,.,SS.I..IL.La annddS S.C.C.O.O. .ccoonncceeiviveeddaannddddeessigignneeddt hthees stutuddyy, ,pprorovvididededfifninanancicailalsusuppppoortr,tc, ocolllelcetcetded and assembled the data, analyzed and interpreted the data, wrote the manuscript, and provided final approval the manuscript. of the manuscript. Funding: This work was supported by the Korea Ginseng Corporation Q1726001 and a Korea University Grant. Funding: This work was supported by the Korea Ginseng Corporation Q1726001 and a Korea University Grant. Acknowledgments: Korean Red Ginseng power was kindly provided by the Korea Ginseng Corporation. We thank Acknowledgments: Korean Red Ginseng power was kindly provided by the Korea Ginseng Corporation. We thank Korea Ginseng Corporation for its support of Korean Red Ginseng powder.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Endoplasmic reticulum stress
  • Korean red ginseng
  • Noxa
  • Reactive oxygen species

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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