La autoantigen enhances translation of Bip mRNA

Yoon Ki Kim; Sung Hoon Back; Jungmin Rho; Song Hee Lee; Sung Key Jang

doi:10.1093/nar/29.24.5009

La autoantigen enhances translation of Bip mRNA

Yoon Ki Kim, Sung Hoon Back, Jungmin Rho, Song Hee Lee, Sung Key Jang

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Translational initiation of the human BiP mRNA is directed by an internal ribosomal entry site (IRES) located in the 5′-untranslated region (5′-UTR). In order to understand the mechanism of the IRES-dependent translation of BiP mRNA, cellular proteins interacting with the BiP IRES were investigated. La autoantigen, which augments the translation of polioviral mRNA and hepatitis C viral mRNA, bound specifically to the second half of the 5′-UTR of the BiP IRES and enhanced translation of BiP mRNA in both in vitro and in vivo assays. This finding suggests that cellular and viral IRESs containing very different RNA sequences may share a common mechanism of translation.

Original language	English
Pages (from-to)	5009-5016
Number of pages	8
Journal	Nucleic acids research
Volume	29
Issue number	24
DOIs	https://doi.org/10.1093/nar/29.24.5009
Publication status	Published - 2001 Dec 24
Externally published	Yes

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nar/29.24.5009

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title = "La autoantigen enhances translation of Bip mRNA",

abstract = "Translational initiation of the human BiP mRNA is directed by an internal ribosomal entry site (IRES) located in the 5′-untranslated region (5′-UTR). In order to understand the mechanism of the IRES-dependent translation of BiP mRNA, cellular proteins interacting with the BiP IRES were investigated. La autoantigen, which augments the translation of polioviral mRNA and hepatitis C viral mRNA, bound specifically to the second half of the 5′-UTR of the BiP IRES and enhanced translation of BiP mRNA in both in vitro and in vivo assays. This finding suggests that cellular and viral IRESs containing very different RNA sequences may share a common mechanism of translation.",

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AU - Kim, Yoon Ki

AU - Back, Sung Hoon

AU - Rho, Jungmin

AU - Lee, Song Hee

AU - Jang, Sung Key

PY - 2001/12/24

Y1 - 2001/12/24

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AB - Translational initiation of the human BiP mRNA is directed by an internal ribosomal entry site (IRES) located in the 5′-untranslated region (5′-UTR). In order to understand the mechanism of the IRES-dependent translation of BiP mRNA, cellular proteins interacting with the BiP IRES were investigated. La autoantigen, which augments the translation of polioviral mRNA and hepatitis C viral mRNA, bound specifically to the second half of the 5′-UTR of the BiP IRES and enhanced translation of BiP mRNA in both in vitro and in vivo assays. This finding suggests that cellular and viral IRESs containing very different RNA sequences may share a common mechanism of translation.

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SN - 0305-1048

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EP - 5016

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 24

ER -

La autoantigen enhances translation of Bip mRNA

Abstract

ASJC Scopus subject areas

UN SDGs

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