TY - JOUR
T1 - Lab-on-a-Contact Lens
T2 - Recent Advances and Future Opportunities in Diagnostics and Therapeutics
AU - Zhu, Yangzhi
AU - Li, Shaopei
AU - Li, Jinghang
AU - Falcone, Natashya
AU - Cui, Qingyu
AU - Shah, Shilp
AU - Hartel, Martin C.
AU - Yu, Ning
AU - Young, Patric
AU - de Barros, Natan Roberto
AU - Wu, Zhuohong
AU - Haghniaz, Reihaneh
AU - Ermis, Menekse
AU - Wang, Canran
AU - Kang, Heemin
AU - Lee, Junmin
AU - Karamikamkar, Solmaz
AU - Ahadian, Samad
AU - Jucaud, Vadim
AU - Dokmeci, Mehmet R.
AU - Kim, Han Jun
AU - Khademhosseini, Ali
N1 - Funding Information:
Y.Z., S.L., and J.L. contributed equally to this work. The authors gratefully acknowledged funding by the National Institutes of Health (CA214411, AR074234, GM126571, TR003148). Finally, the authors acknowledge our colleagues from the Terasaki Institute for Biomedical Innovation, the University of California, Los Angeles, the University of California, San Diego, and the University of California, Riverside, for the excellent collaboration.
Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/6/16
Y1 - 2022/6/16
N2 - The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.
AB - The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.
KW - bioelectronics
KW - biosensors
KW - contact lens
KW - diagnostics
KW - integrated systems
KW - personalized healthcare
KW - therapeutics
KW - wearable electronics
UR - http://www.scopus.com/inward/record.url?scp=85127961538&partnerID=8YFLogxK
U2 - 10.1002/adma.202108389
DO - 10.1002/adma.202108389
M3 - Review article
C2 - 35130584
AN - SCOPUS:85127961538
SN - 0935-9648
VL - 34
JO - Advanced Materials
JF - Advanced Materials
IS - 24
M1 - 2108389
ER -
