TY - JOUR
T1 - Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis
T2 - a meta-analysis.
AU - Lee, Young H.
AU - Song, Gwan G.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2009/11
Y1 - 2009/11
N2 - OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.
AB - OBJECTIVES: Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-alpha promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-alpha promoter polymorphisms confer susceptibility to AS. METHODS: We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-alpha -308 and -238 polymorphisms with AS. RESULTS: Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-alpha -308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I(2) = 73.8]. There was also no association of the TNF-alpha -308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-alpha -238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I(2) = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-alpha -308 and -238 polymorphisms with AS. CONCLUSIONS: This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-alpha -308 A/G and -238 A/G polymorphisms with AS.
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U2 - 10.1093/rheumatology/kep260
DO - 10.1093/rheumatology/kep260
M3 - Review article
C2 - 19720680
AN - SCOPUS:73349132069
SN - 1462-0324
VL - 48
SP - 1359
EP - 1362
JO - Rheumatology and Rehabilitation
JF - Rheumatology and Rehabilitation
IS - 11
ER -