Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

Jaeyoung Kwon, Hyaemin Lee, Yeo Dae Yoon, Bang Yeon Hwang, Yuanqiang Guo, Jong Soon Kang, Jae Jin Kim, Dongho Lee

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.

    Original languageEnglish
    Pages (from-to)1689-1693
    Number of pages5
    JournalJournal of Natural Products
    Volume79
    Issue number6
    DOIs
    Publication statusPublished - 2016 Jun 24

    Bibliographical note

    Funding Information:
    This research was supported by a grant from the National Research Foundation of Korea ( NRF-2015R1D1A1A01060321) and the KRIBB Research Initiative Program.

    Publisher Copyright:
    © 2016 The American Chemical Society and American Society of Pharmacognosy.

    Copyright:
    Copyright 2017 Elsevier B.V., All rights reserved.

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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