Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

Jaeyoung Kwon, Hyaemin Lee, Yeo Dae Yoon, Bang Yeon Hwang, Yuanqiang Guo, Jong Soon Kang, Jae Jin Kim, Dongho Lee

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.

Original languageEnglish
Pages (from-to)1689-1693
Number of pages5
JournalJournal of Natural Products
Volume79
Issue number6
DOIs
Publication statusPublished - 2016 Jun 24

Bibliographical note

Funding Information:
This research was supported by a grant from the National Research Foundation of Korea ( NRF-2015R1D1A1A01060321) and the KRIBB Research Initiative Program.

Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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