LED and CMOS image sensor based hemoglobin concentration measurement technique

Dong Sik Kim; Jae Hoon Choi; Myung Hyun Nam; Ji Woon Yang; James Jungho Pak; Sungkyu Seo

doi:10.1016/j.snb.2011.03.032

LED and CMOS image sensor based hemoglobin concentration measurement technique

Dong Sik Kim, Jae Hoon Choi, Myung Hyun Nam, Ji Woon Yang, James Jungho Pak, Sungkyu Seo

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

This paper presents a technique that can provide accurate hemoglobin concentration measurement within a simple, cost-effective and compact platform. It is based on a LED and CMOS image sensor without using an environmentally harmful reagent and centrifugal process. The acquired standard curve and adequate image processing steps such as image calibration and noise suppression allow us to accurately estimate the hemoglobin concentration at an error rate of less than 2% for blind tests conducted with the 33 blood specimens of outpatients. The hemoglobin concentration measurement, one of the crucial part of the complete blood count (CBC) as well as the most commonly ordered test in clinical laboratory, within such a small, cheap and fast platform would be useful for wide applications in doctor's office and for applications in resource limited settings as a point-of-care testing tool.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/j.snb.2011.03.032
Publication status	Published - 2011 Sept 20

Bibliographical note

Funding Information:
This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (no. 20090083290 ).

Keywords

Blood analysis
CMOS image sensor
Hemoglobin concentration measurement
LED
Spectrophotometry

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2011.03.032

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title = "LED and CMOS image sensor based hemoglobin concentration measurement technique",

abstract = "This paper presents a technique that can provide accurate hemoglobin concentration measurement within a simple, cost-effective and compact platform. It is based on a LED and CMOS image sensor without using an environmentally harmful reagent and centrifugal process. The acquired standard curve and adequate image processing steps such as image calibration and noise suppression allow us to accurately estimate the hemoglobin concentration at an error rate of less than 2% for blind tests conducted with the 33 blood specimens of outpatients. The hemoglobin concentration measurement, one of the crucial part of the complete blood count (CBC) as well as the most commonly ordered test in clinical laboratory, within such a small, cheap and fast platform would be useful for wide applications in doctor's office and for applications in resource limited settings as a point-of-care testing tool.",

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note = "Funding Information: This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (no. 20090083290 ). ",

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AU - Kim, Dong Sik

AU - Choi, Jae Hoon

AU - Nam, Myung Hyun

AU - Yang, Ji Woon

AU - Pak, James Jungho

AU - Seo, Sungkyu

N1 - Funding Information: This research was supported by the Converging Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (no. 20090083290 ).

PY - 2011/9/20

Y1 - 2011/9/20

N2 - This paper presents a technique that can provide accurate hemoglobin concentration measurement within a simple, cost-effective and compact platform. It is based on a LED and CMOS image sensor without using an environmentally harmful reagent and centrifugal process. The acquired standard curve and adequate image processing steps such as image calibration and noise suppression allow us to accurately estimate the hemoglobin concentration at an error rate of less than 2% for blind tests conducted with the 33 blood specimens of outpatients. The hemoglobin concentration measurement, one of the crucial part of the complete blood count (CBC) as well as the most commonly ordered test in clinical laboratory, within such a small, cheap and fast platform would be useful for wide applications in doctor's office and for applications in resource limited settings as a point-of-care testing tool.

AB - This paper presents a technique that can provide accurate hemoglobin concentration measurement within a simple, cost-effective and compact platform. It is based on a LED and CMOS image sensor without using an environmentally harmful reagent and centrifugal process. The acquired standard curve and adequate image processing steps such as image calibration and noise suppression allow us to accurately estimate the hemoglobin concentration at an error rate of less than 2% for blind tests conducted with the 33 blood specimens of outpatients. The hemoglobin concentration measurement, one of the crucial part of the complete blood count (CBC) as well as the most commonly ordered test in clinical laboratory, within such a small, cheap and fast platform would be useful for wide applications in doctor's office and for applications in resource limited settings as a point-of-care testing tool.

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KW - CMOS image sensor

KW - Hemoglobin concentration measurement

KW - LED

KW - Spectrophotometry

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LED and CMOS image sensor based hemoglobin concentration measurement technique

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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