Leukotriene B4receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production

Donghwan Park, Dong Wook Kwak, Jae Hong Kim

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Leukotriene B4(LTB4) is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. Previous studies have reported that the receptors of LTB4, BLT1, and BLT2 play mediatory roles in the allergic airway inflammation induced by ovalbumin (OVA). However, considering that house dust mites (HDMs) are the most prevalent allergen and well-known risk factor for asthmatic allergies, we are interested in elucidating the contributory roles of BLT1/2 in HDMinduced allergic airway inflammation. Our aim in this study was to investigate whether BLT1/2 play any roles in HDM-induced allergic airway inflammation. In this study, we observed that the levels of ligands for BLT1/2 [LTB4and 12(S)-HETE (12(S)-hydroxyeicosatetraenoic acid)] were significantly increased in bronchoalveolar lavage fluid (BALF) after HDM challenge. Blockade of BLT1 or BLT2 as well as of 5-lipoxygenase (5-LO) or 12-lipoxygenase (12-LO) markedly suppressed the production of TH2 cytokines (IL-4, IL-5, and IL-13) and alleviated lung inflammation and mucus secretion in an HDM-induced eosinophilic airway-inflammation mouse model. Together, these results indicate that the 5-/12-LO-BLT1/2 cascade plays a role in HDMinduced airway inflammation by mediating the production of TH2 cytokines. Our findings suggest that BLT1/2 may be a potential therapeutic target for patients with HDM-induced allergic asthma.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalBMB reports
Issue number3
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This work was supported by a Bio & Medical Technology Development Program Grant (2017M3A9D8063317) and a Mid-Career Researcher Program Grant (2020R1A2B5B01002046) through the National Research Foundation funded by the Ministry of Science, Information, and Communication Technologies (ICT) and Future Planning, Republic of Korea. This work was also supported by Korea University grant.

Publisher Copyright:
Copyright © 2021 by the The Korean Society for Biochemistry and Molecular Biology


  • BLT1
  • BLT2
  • Eosinophilic airway inflammation
  • HDM
  • T2 cytokine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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