Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea

Hyung Joon Yim; Kwan Soo Byun; Yun Jung Chang; Yeon Seok Suh; Jong Eun Yeon; Chang Hong Lee; Jung Ah Kwon; Wangdon Yoo; Soo Ok Kim; Sun Pyo Hong

doi:10.1007/s10620-006-9140-2

Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea

Hyung Joon Yim, Kwan Soo Byun, Yun Jung Chang, Yeon Seok Suh, Jong Eun Yeon, Chang Hong Lee, Jung Ah Kwon, Wangdon Yoo, Soo Ok Kim, Sun Pyo Hong

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6×10⁴ copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.

Original language	English
Pages (from-to)	2403-2409
Number of pages	7
Journal	Digestive Diseases and Sciences
Volume	52
Issue number	9
DOIs	https://doi.org/10.1007/s10620-006-9140-2
Publication status	Published - 2007 Sept

Keywords

HBsAg loss
Hepatitis B virus DNA
Inactive HBsAg carriers
Nonreplicative phase
Real-time PCR

ASJC Scopus subject areas

Physiology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10620-006-9140-2

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@article{34a1513113b945c88ff13d7d6310f6e4,

title = "Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea",

abstract = "The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6×104 copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.",

keywords = "HBsAg loss, Hepatitis B virus DNA, Inactive HBsAg carriers, Nonreplicative phase, Real-time PCR",

author = "Yim, {Hyung Joon} and Byun, {Kwan Soo} and Chang, {Yun Jung} and Suh, {Yeon Seok} and Yeon, {Jong Eun} and Lee, {Chang Hong} and Kwon, {Jung Ah} and Wangdon Yoo and Kim, {Soo Ok} and Hong, {Sun Pyo}",

year = "2007",

month = sep,

doi = "10.1007/s10620-006-9140-2",

language = "English",

volume = "52",

pages = "2403--2409",

journal = "American Journal of Digestive Diseases",

issn = "0002-9211",

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T2 - HBV quantification by real-time PCR in Korea

AU - Yim, Hyung Joon

AU - Byun, Kwan Soo

AU - Chang, Yun Jung

AU - Suh, Yeon Seok

AU - Yeon, Jong Eun

AU - Lee, Chang Hong

AU - Kwon, Jung Ah

AU - Yoo, Wangdon

AU - Kim, Soo Ok

AU - Hong, Sun Pyo

PY - 2007/9

Y1 - 2007/9

N2 - The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6×104 copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.

AB - The levels of HBV replication in the nonreplicative phase are not clear. We conducted this study to evaluate the levels of viral replication during the nonreplicative phase in chronic HBV-infected Korean patients using real-time PCR. A total of 125 patients were classified into three groups: inactive HBsAg carriers, inactive liver cirrhosis patients, and resolved chronic HBV-infected patients with loss of HBsAg. The real-time PCR detected HBV DNA in 112 cases (89.6%). The mean levels of HBV DNA were 3.84, 4.10, and 3.31 log copies/ml in the three groups, respectively (P <0.01). Ninety-five percent of inactive HBsAg carriers showed levels of HBV DNA lower than 6×104 copies/ml. In conclusion, we showed different levels of HBV DNA exactly in three groups during nonreplicative phases. We suggest that the cutoff level of HBV DNA in inactive HBsAg carriers should be readjusted to a lower level in future studies.

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KW - Hepatitis B virus DNA

KW - Inactive HBsAg carriers

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Levels of hepatitis B virus (HBV) replication during the nonreplicative phase: HBV quantification by real-time PCR in Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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