Lifestyle-dependent brain change: a longitudinal cohort MRI study

Regina EY Kim; Chang Ho Yun; Robert J. Thomas; Jang Hoon Oh; Hans J. Johnson; Soriul Kim; Seungku Lee; Hyung Suk Seo; Chol Shin

doi:10.1016/j.neurobiolaging.2018.04.017

Lifestyle-dependent brain change: a longitudinal cohort MRI study

Regina EY Kim, Chang Ho Yun, Robert J. Thomas, Jang Hoon Oh, Hans J. Johnson, Soriul Kim, Seungku Lee, Hyung Suk Seo, Chol Shin

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.

Original language	English
Pages (from-to)	48-57
Number of pages	10
Journal	Neurobiology of Aging
Volume	69
DOIs	https://doi.org/10.1016/j.neurobiolaging.2018.04.017
Publication status	Published - 2018 Sept

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Aging
Brain atrophy
Lifestyle
Longitudinal MRI

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Ageing
General Neuroscience
Developmental Biology

Access to Document

10.1016/j.neurobiolaging.2018.04.017

Cite this

@article{3b72485e8888420cbdd36b46888e863d,

title = "Lifestyle-dependent brain change: a longitudinal cohort MRI study",

abstract = "We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.",

keywords = "Aging, Brain atrophy, Lifestyle, Longitudinal MRI",

author = "Kim, {Regina EY} and Yun, {Chang Ho} and Thomas, {Robert J.} and Oh, {Jang Hoon} and Johnson, {Hans J.} and Soriul Kim and Seungku Lee and Seo, {Hyung Suk} and Chol Shin",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = sep,

doi = "10.1016/j.neurobiolaging.2018.04.017",

language = "English",

volume = "69",

pages = "48--57",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Lifestyle-dependent brain change

T2 - a longitudinal cohort MRI study

AU - Kim, Regina EY

AU - Yun, Chang Ho

AU - Thomas, Robert J.

AU - Oh, Jang Hoon

AU - Johnson, Hans J.

AU - Kim, Soriul

AU - Lee, Seungku

AU - Seo, Hyung Suk

AU - Shin, Chol

PY - 2018/9

Y1 - 2018/9

N2 - We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.

AB - We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.

KW - Aging

KW - Brain atrophy

KW - Lifestyle

KW - Longitudinal MRI

UR - http://www.scopus.com/inward/record.url?scp=85054317493&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2018.04.017

DO - 10.1016/j.neurobiolaging.2018.04.017

M3 - Article

C2 - 29852410

AN - SCOPUS:85054317493

SN - 0197-4580

VL - 69

SP - 48

EP - 57

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Lifestyle-dependent brain change: a longitudinal cohort MRI study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this