@article{3b72485e8888420cbdd36b46888e863d,
title = "Lifestyle-dependent brain change: a longitudinal cohort MRI study",
abstract = "We investigated both independent and interconnected effects of 3 lifestyle factors on brain volume, measuring yearly changes using large-scale longitudinal magnetic resonance imaging, in middle-aged to older adults. We measured brain volumes in a cohort (n = 984, 49–79 years) from the Korean Genome and Epidemiology Study group, using baseline and follow-up estimates after 4 years. In our analysis, the accelerated brain atrophy in normal aging was observed across regions (e.g., brain tissue: -0.098 ± 0.01 mL/y, p < 0.001). An independent lifestyle-specific trend of brain atrophy across time was also evident in men, where smoking (p = 0.012) and physical activity (p = 0.014) showed the strongest association with the atrophy rate. Linear regression analysis of the interconnected effect revealed that brain atrophy is mitigated by intense physical activity in smoking males. Lifestyle factors did not show any significant effect on brain volume in women. These results provide important information regarding lifestyle factors that affect brain aging in mid-to-late adulthood. Our findings may aid in the identification of preventive measures against dementia.",
keywords = "Aging, Brain atrophy, Lifestyle, Longitudinal MRI",
author = "Kim, {Regina EY} and Yun, {Chang Ho} and Thomas, {Robert J.} and Oh, {Jang Hoon} and Johnson, {Hans J.} and Soriul Kim and Seungku Lee and Seo, {Hyung Suk} and Chol Shin",
note = "Funding Information: The authors would like to acknowledge Hyeryeoung Nam, Sol Park, SM Lee, KS Kim, MJ Cha, and all members of KoGES for their assistance in completing this analysis. The authors thank the KoGES Ansan sites and the study participants. This research was supported by funds from the Korea Centers for Disease Control and Prevention (2011-E71004-00, 2012-E71005-00, 2013-E71005-00, 2014-E71003-00, 2015-P71001-00, and 2016-E71003-00), the Ministry of Science, ICT & Future Planning [No. 2012–0009830], and in part through computational resources provided by The University of Iowa, Iowa City, Iowa. Funding Information: The authors would like to acknowledge Hyeryeoung Nam, Sol Park, SM Lee, KS Kim, MJ Cha, and all members of KoGES for their assistance in completing this analysis. The authors thank the KoGES Ansan sites and the study participants. This research was supported by funds from the Korea Centers for Disease Control and Prevention ( 2011-E71004-00 , 2012-E71005-00 , 2013-E71005-00 , 2014-E71003-00 , 2015-P71001-00 , and 2016-E71003-00 ), the Ministry of Science, ICT & Future Planning [No. 2012–0009830 ], and in part through computational resources provided by The University of Iowa , Iowa City, Iowa. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = sep,
doi = "10.1016/j.neurobiolaging.2018.04.017",
language = "English",
volume = "69",
pages = "48--57",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}