Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations

Seon Mee Kim, Geum Joo Cho, Mary Yannakoulia, Taik Gun Hwang, In Hee Kim, Eun Kyung Park, Christos S. Mantzoros

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33 Citations (Scopus)


The objective of the study was to evaluate the effects of a 10-month lifestyle intervention on the components of the metabolic syndrome (MetSyn) in Koreans with MetSyn as well as on blood concentrations of adiponectin and vaspin. One hundred thirty-eight patients with MetSyn, recruited from a community health care center, were consecutively enrolled in the study; 12 patients dropped of the intervention, leaving 126 subjects (76 men and 50 women; age, 65.3 ± 9.0 years). All participants followed a 10-month lifestyle modification interventional program, including dietary counseling, advice on increasing physical activity, and recommendations to stop or limit smoking and alcohol drinking. Anthropometric and biochemical parameters related to the components of the MetSyn, including blood concentrations of adiponectin and vaspin, were assessed pre- and postintervention. At baseline, adiponectin concentrations were moderately negatively correlated to insulin concentrations and insulin resistance evaluated by the homeostasis model assessment. In response to lifestyle modification, statistically significant changes were found in systolic and diastolic blood pressure, total cholesterol, triglyceride, and insulin concentrations, as well as in homeostasis model assessment of insulin resistance. Adiponectin concentrations postintervention, compared with the preintervention levels, increased (7.2 ± 4.0 vs 6.8 ± 3.9 μg/mL, respectively; P <.05), whereas vaspin concentrations remained unchanged (0.25 ± 0.19 vs 0.26 ± 0.20 ng/mL, respectively; P =.64). A 10-month lifestyle modification program in Korean patients with MetSyn led to favorable changes in metabolic parameters and adiponectin but not vaspin concentrations.

Original languageEnglish
Pages (from-to)1294-1299
Number of pages6
JournalMetabolism: Clinical and Experimental
Issue number9
Publication statusPublished - 2011 Sept
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant ( 10526 ) from the Korean Seoul City Research and Business Development Program (SM Kim). The academic sabbatical of M Yannakoulia in the Mantzoros Laboratory has been supported by the Fulbright Foundation in Greece. This study was also supported by a discretionary grant from Beth Israel Deaconess Medical Center and National Institute of Diabetes and Digestive and Kidney Diseases grants DK 58785 , DK 79929 , and DK 81913 (CS Mantzoros).

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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