Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

So Young Park; Seong Su Hong; Xiang Hua Han; Ji Sang Hwang; Dongho Lee; Jai Seup Ro; Bang Yeon Hwang

doi:10.1248/cpb.55.150

Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

So Young Park, Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Dongho Lee, Jai Seup Ro, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC₅₀ values of 9.5 and 9.6 μM, respectively.

Original language	English
Pages (from-to)	150-152
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	1
DOIs	https://doi.org/10.1248/cpb.55.150
Publication status	Published - 2007 Jan

Keywords

Arctium lappa
Compositae
Isolappaol C
Lignan
Nitric oxide production inhibitor

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.55.150

Cite this

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title = "Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production",

abstract = "A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC50 values of 9.5 and 9.6 μM, respectively.",

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AU - Lee, Dongho

AU - Ro, Jai Seup

AU - Hwang, Bang Yeon

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Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production

Abstract

Keywords

ASJC Scopus subject areas

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