TY - JOUR
T1 - Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production
AU - Jin, Qinghao
AU - Lee, Jin Woo
AU - Kim, Jun Gu
AU - Lee, Dongho
AU - Hong, Jin Tae
AU - Kim, Youngsoo
AU - Lee, Mi Kyeong
AU - Hwang, Bang Yeon
N1 - Funding Information:
This research was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea. The authors wish to thank the Korea Basic Science Institute for the NMR spectroscopic measurements.
Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.
PY - 2019/11/22
Y1 - 2019/11/22
N2 - Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4′-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.
AB - Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4′-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85074281653&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b00520
DO - 10.1021/acs.jnatprod.9b00520
M3 - Article
C2 - 31642320
AN - SCOPUS:85074281653
SN - 0163-3864
VL - 82
SP - 3002
EP - 3009
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -