Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

Qinghao Jin; Jin Woo Lee; Jun Gu Kim; Dongho Lee; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.9b00520

Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

Qinghao Jin, Jin Woo Lee, Jun Gu Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4′-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC₅₀ values of 5.6, 8.6, and 9.2 μM, respectively.

Original language	English
Pages (from-to)	3002-3009
Number of pages	8
Journal	Journal of Natural Products
Volume	82
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00520
Publication status	Published - 2019 Nov 22

Bibliographical note

Funding Information:
This research was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea. The authors wish to thank the Korea Basic Science Institute for the NMR spectroscopic measurements.

Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.9b00520

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title = "Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production",

abstract = "Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4′-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.",

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AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea. The authors wish to thank the Korea Basic Science Institute for the NMR spectroscopic measurements. Publisher Copyright: © 2019 American Chemical Society and American Society of Pharmacognosy.

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Y1 - 2019/11/22

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Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

Abstract

Bibliographical note

ASJC Scopus subject areas

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