We investigated hypocholesterolemic mechanisms of linalool, an aromatic anti-oxidative monoterpene, which is abundant in teas and essential oils. Oral administration of linalool to mice for 6 weeks significantly lowered total and low-density lipoprotein cholesterol concentrations, and HMG-CoA reductase protein expression (-46%; P < 0.05) by both transcriptional and posttranscriptional mechanisms. Linalool suppressed the gene expression of HMG-CoA reductase by reducing the binding of SREBP-2 to its promoter, as assessed by qPCR and chromatin immunoprecipitation, and by inducing ubiquitin-dependent proteolysis of the HMG-CoA reductase. These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms.
Bibliographical noteFunding Information:
We thank Dr. Mi Ja Chung for initial contributions to the project and Hyo-Min Park for technical assistance. This was supported by a grant from the BioGreen 21 Program, Rural Development Administration, Republic of Korea ( 20080401034049 ), and by the Forest Science and Technology Projects (Project No. S120909L130110 ) of the Korea Forest Service, and with the support of “ Cooperative Research Program for Agricultural Science and Technology Development ( 201104010305070010300 )”, Rural Development Administration, Republic of Korea.
- HMG-CoA reductase
- Sterol regulatory element binding protein-2
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology
- Cell Biology