Liver cirrhosis induced by porphyria cutanea tarda: A case report and review

Kwang Gyun Lee; Jong Jin Hyun; Yeon Seok Seo; Bora Keum; Hyung Joon Yim; Yoon Tae Jeen; Hong Sik Lee; Hoon Jai Chun; Chang Duck Kim; Ho Sang Ryu; Soon Ho Um

doi:10.5009/gnl.2010.4.4.551

Liver cirrhosis induced by porphyria cutanea tarda: A case report and review

Kwang Gyun Lee, Jong Jin Hyun, Yeon Seok Seo, Bora Keum, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu, Soon Ho Um

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

Original language	English
Pages (from-to)	551-555
Number of pages	5
Journal	Gut and liver
Volume	4
Issue number	4
DOIs	https://doi.org/10.5009/gnl.2010.4.4.551
Publication status	Published - 2010 Dec
Externally published	Yes

Keywords

Liver cirrhosis
Metabolic disorder
Porphyria cutanea tarda
Uroporphyrin

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.5009/gnl.2010.4.4.551

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title = "Liver cirrhosis induced by porphyria cutanea tarda: A case report and review",

abstract = "Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.",

keywords = "Liver cirrhosis, Metabolic disorder, Porphyria cutanea tarda, Uroporphyrin",

author = "Lee, {Kwang Gyun} and Hyun, {Jong Jin} and Seo, {Yeon Seok} and Bora Keum and Yim, {Hyung Joon} and Jeen, {Yoon Tae} and Lee, {Hong Sik} and Chun, {Hoon Jai} and Kim, {Chang Duck} and Ryu, {Ho Sang} and Um, {Soon Ho}",

year = "2010",

month = dec,

doi = "10.5009/gnl.2010.4.4.551",

language = "English",

volume = "4",

pages = "551--555",

journal = "Gut and liver",

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T1 - Liver cirrhosis induced by porphyria cutanea tarda

T2 - A case report and review

AU - Lee, Kwang Gyun

AU - Hyun, Jong Jin

AU - Seo, Yeon Seok

AU - Keum, Bora

AU - Yim, Hyung Joon

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Chun, Hoon Jai

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

AU - Um, Soon Ho

PY - 2010/12

Y1 - 2010/12

N2 - Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

AB - Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

KW - Liver cirrhosis

KW - Metabolic disorder

KW - Porphyria cutanea tarda

KW - Uroporphyrin

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U2 - 10.5009/gnl.2010.4.4.551

DO - 10.5009/gnl.2010.4.4.551

M3 - Review article

C2 - 21253308

AN - SCOPUS:78650638459

SN - 1976-2283

VL - 4

SP - 551

EP - 555

JO - Gut and liver

JF - Gut and liver

IS - 4

ER -

Liver cirrhosis induced by porphyria cutanea tarda: A case report and review

Abstract

Keywords

ASJC Scopus subject areas

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