Liver-Specific Deletion of Mouse CTCF Leads to Hepatic Steatosis via Augmented PPARγ Signaling

Keyphrases

• Peroxisome Proliferator-activated Receptor 100%
• Hepatic Steatosis 100%
• Liver-specific 100%
• Receptor Signaling 100%
• Liver 83%
• Cluster of Differentiation 36 (CD36) 50%
• Lipids 33%
• Knockdown 33%
• Adenovirus 33%
• Gene-deficient Mice 33%
• Downstream Target Genes 33%
• Lipid Metabolic Process 33%
• Hepatic Inflammation 33%
• Gene Regulation 16%
• DNA Binding 16%
• Knock-in Mouse Model 16%
• Overexpression 16%
• Physiological Role 16%
• Chromatin Immunoprecipitation (ChIP) 16%
• Standard Chow 16%
• Non-alcoholic Fatty Liver Disease (NAFLD) 16%
• Chow Diet 16%
• Hepatosteatosis 16%
• Pharmacologic 16%
• Whole-body 16%
• Zinc Finger Protein 16%
• RNA Sequencing (RNA-seq) 16%
• Hepatic Lipid Metabolism 16%
• Enhanced Accumulation 16%
• Major Organs 16%
• Global Analysis 16%
• Health Anxiety 16%
• Transcriptome Landscape 16%
• Fat Storage 16%
• Regulation Process 16%
• CCCTC-binding Factor 16%
• Chromatin Interactions 16%
• H3K27 Acetylation 16%
• Enhancer Landscape 16%
• In Situ Hi-C 16%
• Higher-order Chromatin Structure 16%
• Genomic Occupancy 16%

Biochemistry, Genetics and Molecular Biology

• Peroxisome Proliferator-Activated Receptor 100%
• CTCF 100%
• Lipid 40%
• CD36 30%
• Adenoviridae 20%
• Binding Affinity 10%
• Chromatin Immunoprecipitation 10%
• Enhancer Region 10%
• Knockout Mouse 10%
• Gene Control 10%
• DNA Binding 10%
• Lipid Storage 10%
• Lipid Metabolism 10%
• Transcriptome 10%
• Acetylation 10%
• Lipid Liver Level 10%
• RNA Sequence 10%
• Transcription Factor CTCF 10%