Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo

Sung Youn Cho; Soo Won Chae; Kui Won Choi; Hyun Kwang Seok; Hyung Seop Han; Seok Jo Yang; Young Yul Kim; Jong Tac Kim; Jae Young Jung; Michel Assad

doi:10.1002/jbm.b.32722

Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo

Sung Youn Cho, Soo Won Chae, Kui Won Choi, Hyun Kwang Seok, Hyung Seop Han, Seok Jo Yang, Young Yul Kim, Jong Tac Kim, Jae Young Jung, Michel Assad

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.

Original language	English
Pages (from-to)	1535-1544
Number of pages	10
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	100 B
Issue number	6
DOIs	https://doi.org/10.1002/jbm.b.32722
Publication status	Published - 2012 Aug

Keywords

biodegradable alloy
degradation rate
implant
load bearing
magnesium

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

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10.1002/jbm.b.32722

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Cho, S. Y., Chae, S. W., Choi, K. W., Seok, H. K., Han, H. S., Yang, S. J., Kim, Y. Y., Kim, J. T., Jung, J. Y., & Assad, M. (2012). Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 100 B(6), 1535-1544. https://doi.org/10.1002/jbm.b.32722

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abstract = "In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.",

keywords = "biodegradable alloy, degradation rate, implant, load bearing, magnesium",

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AU - Cho, Sung Youn

AU - Chae, Soo Won

AU - Choi, Kui Won

AU - Seok, Hyun Kwang

AU - Han, Hyung Seop

AU - Yang, Seok Jo

AU - Kim, Young Yul

AU - Kim, Jong Tac

AU - Jung, Jae Young

AU - Assad, Michel

PY - 2012/8

Y1 - 2012/8

N2 - In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.

AB - In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.

KW - biodegradable alloy

KW - degradation rate

KW - implant

KW - load bearing

KW - magnesium

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Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo

Abstract

Keywords

ASJC Scopus subject areas

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