Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - 2022 Nov 12|
Bibliographical noteFunding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea ( NRF ) funded by the Korean government ( MSIT ) 2014M3A9D3034158 , 2014M3A9D3034164 , 2016R1C1B1011180 , 2018R1C1B5040264 , 2019R1A2C1004046 , 2019R1F1A1044473 , and 2019R1H1A1079839 , and by the Ministry of Trade, Industry, and Energy ( R0005886 ). This work was also supported by the School of Life Sciences and Biotechnology for BK21 PLUS , Korea University .
- Chronic kidney disease
- Diabetic nephropathy
- Induced nephron progenitor cells
- Renal repair
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology