Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Wei Wei Gao; So Young Chun; Bum Soo Kim; Yun Sok Ha; Jun Nyung Lee; Eun Hye Lee; In Yong Kim; Seungkwon You; Tae Gyun Kwon

doi:10.1016/j.bbrc.2022.09.015

Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Wei Wei Gao
, So Young Chun
, Bum Soo Kim
, Yun Sok Ha
, Jun Nyung Lee
, Eun Hye Lee
, In Yong Kim^*
, Seungkwon You^*
, Tae Gyun Kwon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.

Original language	English
Pages (from-to)	128-134
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	629
DOIs	https://doi.org/10.1016/j.bbrc.2022.09.015
Publication status	Published - 2022 Nov 12

Bibliographical note

Publisher Copyright:
© 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic kidney disease
Diabetic nephropathy
Induced nephron progenitor cells
Renal repair

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/j.bbrc.2022.09.015

Cite this

@article{d45e6c63804c48499da6c6e47261e7e7,

title = "Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy",

abstract = "Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.",

keywords = "Chronic kidney disease, Diabetic nephropathy, Induced nephron progenitor cells, Renal repair",

author = "Gao, \{Wei Wei\} and Chun, \{So Young\} and Kim, \{Bum Soo\} and Ha, \{Yun Sok\} and Lee, \{Jun Nyung\} and Lee, \{Eun Hye\} and Kim, \{In Yong\} and Seungkwon You and Kwon, \{Tae Gyun\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = nov,

day = "12",

doi = "10.1016/j.bbrc.2022.09.015",

language = "English",

volume = "629",

pages = "128--134",

journal = "Biochemical and biophysical research communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

AU - Gao, Wei Wei

AU - Chun, So Young

AU - Kim, Bum Soo

AU - Ha, Yun Sok

AU - Lee, Jun Nyung

AU - Lee, Eun Hye

AU - Kim, In Yong

AU - You, Seungkwon

AU - Kwon, Tae Gyun

PY - 2022/11/12

Y1 - 2022/11/12

N2 - Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.

AB - Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic nephropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell-derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for transplantation in patients with kidney diseases.

KW - Chronic kidney disease

KW - Diabetic nephropathy

KW - Induced nephron progenitor cells

KW - Renal repair

UR - https://www.scopus.com/pages/publications/85138095554

U2 - 10.1016/j.bbrc.2022.09.015

DO - 10.1016/j.bbrc.2022.09.015

M3 - Article

C2 - 36116375

AN - SCOPUS:85138095554

SN - 0006-291X

VL - 629

SP - 128

EP - 134

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

ER -

Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this