Long-term air pollution exposure is associated with higher incidence of ST-elevation myocardial infarction and in-hospital cardiogenic shock

Jinah Cha, Se Yeon Choi, Seung Woon Rha, Byoung Geol Choi, Jae Kyeong Byun, Sujin Hyun, Min Woo Lee, Jaeho Kang, Wonsang Chu, Eun Jin Park, Dong Oh Kang, Cheol Ung Choi, Suhng Wook Kim, Myung Ho Jeong, Soohyung Park, Seung Woon Rha, Tae Hoon Ahn, Junghan Yoon, Hyo Soo Kim, Ki Bae SeungHyeon Cheol Gwon, Shung Chull Chae, Chong Jin Kim, Kwang Soo Cha, Jung Hee Lee, Jei Keon Chae, Seung Jae Joo, Chang Hwan Yoon, Seung Ho Hur, In Whan Seong, Kyung Kuk Hwang, Doo Il Kim, Seok Kyu Oh, Jin Yong Hwang, Myung Ho Jeong

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Abstract

Previous studies have reported the association between myocardial infarction (MI) and air pollution (AP). However, limited information is available regarding the long-term effects of AP on the relative incidence rates of ST-elevation MI (STEMI) and Non-ST-elevation MI (NSTEMI). We investigated the association between long-term exposure to AP and the incidence of STEMI. Between January 2006 and December 2015, a total of 45,619 eligible patients with Acute Myocardial Infarction (AMI) were enrolled in the Korea Acute MI Registry (KAMIR) and KAMIR-National Institutes of Health. Mixed-effect regression models were used to examine the association between the annual average ambient AP before MI onset and the incidence of STEMI, and to evaluate the association of AP with the incidence of in-hospital cardiogenic shock. After mixed-effect regression model analysis, particulate matter (PM) 10 µm or less in diameter (PM10) was associated with increased incidence of STEMI compared with NSTEMI (odds ratio [OR] 1.009, 95% Confidence Interval [CI] 1.002–1.016; p = 0.012). For in-hospital cardiogenic shock complication, PM10 and SO2 were associated with increased risk, PM10 (OR 1.033, 95% CI 1.018–1.050; p < 0.001), SO2 (OR 1.104, 95% CI 1.006–1.212; p = 0.037), respectively. Policy-level strategies and clinical efforts to reduce AP exposure are necessary to prevent the incidence of STEMI and severe cardiovascular complications.

Original languageEnglish
Article number4976
JournalScientific reports
Volume14
Issue number1
DOIs
Publication statusPublished - 2024 Dec

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© The Author(s) 2024.

ASJC Scopus subject areas

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