Long-term Outcomes of Antiviral Therapy in Patients With Advanced Chronic HBV Infection

Soul Study Group

    Research output: Contribution to journalShort surveypeer-review

    8 Citations (Scopus)


    Hepatitis B virus (HBV) suppression with nucleot(s)ide analogue therapy reduces the risk of hepatic decompensation and hepatocellular carcinoma (HCC) in patients with advanced liver disease.1 In the present era of potent antiviral therapies, the prognostic significance of the serum HBV DNA level as a biological gradient has substantially diminished; the majority of treated patients achieve virologic suppression.2,3 After control of viremia, a higher baseline fibrosis level is a useful predictor for disease progression.4 Few “prospective” studies on the effects of antiviral agents, especially in chronic hepatitis B (CHB) patients with advanced liver disease, have been reported.

    Original languageEnglish
    Pages (from-to)2811-2813.e1
    JournalClinical Gastroenterology and Hepatology
    Issue number13
    Publication statusPublished - 2019 Dec

    Bibliographical note

    Funding Information:
    Funding This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020). This investigator-initiated trial was provided the study drug from Bristol-Myers Squibb. Bristol-Myers Squibb had no role in the study design, data collection, and analysis. The authors retain full responsibility.

    Publisher Copyright:
    © 2019 AGA Institute

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology


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