TY - JOUR
T1 - Long-term prognostic factors for cardiovascular events in patients with chest pain without diabetes mellitus nor significant coronary stenosis
AU - Rha, Seung Woon
AU - Lee, Kyuho
AU - Choi, Se Yeon
AU - Byun, Jae Kyeong
AU - Cha, Jinah
AU - Hyun, Sujin
AU - Ahn, Woo Jin
AU - Park, Soohyung
AU - Kang, Dong Oh
AU - Park, Eun Jin
AU - Choi, Cheol Ung
AU - Choi, Byoung Geol
N1 - Publisher Copyright:
© Springer Nature Japan KK, part of Springer Nature 2024. corrected publication 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Chest pain is the most common symptom of coronary artery disease (CAD) and diabetes mellitus (DM) is a well-known single strongest risk factor for cardiovascular diseases. Thus, the impact of CAD nor DM on long-term clinical effects is reported widely, but the prognostic factors of non-DM patients presenting with chest pain without significant CAD are limited. A total of 1,046 patients with chest pain without DM and significant CAD who underwent coronary angiography (CAG) and acetylcholine (ACH) provocation tests were finally enrolled. Propensity score matching and multivariate Cox-proportional hazard ratio analysis were performed to adjust for baseline potential confounders. Major adverse cardiac and cerebrovascular events (MACCE) were defined as the composite of total death, myocardial infarction (MI), revascularization, stroke, and recurrent angina. This study aimed to evaluate the long-term prognostic factors for MACCE in patients with chest pain without DM and CAD up to 5 years. Coronary artery spasm (CAS) was the most common cause of chest pain. However, long-term MACCE of CAS was not worse than those of patients with chest pain without CAS when patients with CAS had subsequent optimal antianginal medication therapy. However, a recurrent chest pain remains a problem even with continuous antianginal medication therapy. Up to 5 years, the incidence of MACCE was in 7.3%, including recurrent angina 6.9%. Dyslipidemia (HR: 2.010, 95% CI 1.166–3.466, P = 0.012), mild–moderate (30–70%) coronary stenosis (HR: 2.369, 95% CI 1.118–5.018, P = 0.024), the use of aspirin (HR: 2.885, 95% CI 1.588–5.238, P < 0.001), and the use of nitrates (HR: 1.938, 95% CI 1.094–3.433, P = 0.023) were independent risk factors for MACCE. Among the patients with chest pain without DM and significant CAD, the incidence of MACE were rare, but recurrent angina was still a challenging problem who had treated with antianginal medications.
AB - Chest pain is the most common symptom of coronary artery disease (CAD) and diabetes mellitus (DM) is a well-known single strongest risk factor for cardiovascular diseases. Thus, the impact of CAD nor DM on long-term clinical effects is reported widely, but the prognostic factors of non-DM patients presenting with chest pain without significant CAD are limited. A total of 1,046 patients with chest pain without DM and significant CAD who underwent coronary angiography (CAG) and acetylcholine (ACH) provocation tests were finally enrolled. Propensity score matching and multivariate Cox-proportional hazard ratio analysis were performed to adjust for baseline potential confounders. Major adverse cardiac and cerebrovascular events (MACCE) were defined as the composite of total death, myocardial infarction (MI), revascularization, stroke, and recurrent angina. This study aimed to evaluate the long-term prognostic factors for MACCE in patients with chest pain without DM and CAD up to 5 years. Coronary artery spasm (CAS) was the most common cause of chest pain. However, long-term MACCE of CAS was not worse than those of patients with chest pain without CAS when patients with CAS had subsequent optimal antianginal medication therapy. However, a recurrent chest pain remains a problem even with continuous antianginal medication therapy. Up to 5 years, the incidence of MACCE was in 7.3%, including recurrent angina 6.9%. Dyslipidemia (HR: 2.010, 95% CI 1.166–3.466, P = 0.012), mild–moderate (30–70%) coronary stenosis (HR: 2.369, 95% CI 1.118–5.018, P = 0.024), the use of aspirin (HR: 2.885, 95% CI 1.588–5.238, P < 0.001), and the use of nitrates (HR: 1.938, 95% CI 1.094–3.433, P = 0.023) were independent risk factors for MACCE. Among the patients with chest pain without DM and significant CAD, the incidence of MACE were rare, but recurrent angina was still a challenging problem who had treated with antianginal medications.
KW - Chest pain
KW - Coronary artery spasm
KW - Diabetes mellitus
KW - Insignificant stenosis
KW - Type 2 diabetes
UR - https://www.scopus.com/pages/publications/85184240112
U2 - 10.1007/s00380-023-02348-4
DO - 10.1007/s00380-023-02348-4
M3 - Article
C2 - 38324195
AN - SCOPUS:85184240112
SN - 0910-8327
JO - Heart and Vessels
JF - Heart and Vessels
ER -
