Long-term renal outcome of biopsy-proven acute tubular necrosis and acute interstitial nephritis

Hyunseo Kim, Sang Kyung Jo, Shin Young Ahn, Young Joo Kwon, Hajeong Lee, Jieun Oh, Ho Jun Chin, Kijoon Lim, Junyong Lee, Jihyun Yang, Myung Gyu Kim, Won Yong Cho, Se Won Oh

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    6 Citations (Scopus)


    Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), long-term renal outcome of AKI still remains unclear. Acute tubular necrosis (ATN) is the most common cause of AKI due to ischemia, toxin or sepsis. Acute interstitial nephritis (AIN), caused by drugs or autoimmune diseases is also increasingly recognized as an important cause of AKI. Unlike glomerular diseases, AKI is usually diagnosed in the clinical context without kidney biopsies, and lack of histology might contribute to this uncertainty. Methods: Among 8,769 biopsy series, 253 adults who were histologically diagnosed with ATN and AIN from 1982 to 2018 at five university hospitals were included. Demographic and pathological features that are associated with the development of end stage renal disease (ESRD) were also examined. Results: Rate of non-recovery of renal function at 6 month was significantly higher in the AIN (ATN vs AIN 49.3 vs 69.4%, P = 0.007) with a 2.71-fold higher risk of non-recovery compared to ATN (95% confidence interval [CI], 1.20-6.47). During the mean follow up of 76.5 ± 91.9 months, ESRD developed in 39.4% of patients with AIN, and 21.5% patients of ATN. The risk of ESRD was significantly higher in AIN (23.05; 95% CI, 2.42-219.53) and also in ATN (12.14; 95% CI, 1.19-24.24) compared to control with non-specific pathology. Older age, female gender, renal function at the time of biopsy and at 6 months, proteinuria and pathological features including interstitial inflammation and fibrosis, tubulitis, vascular lesion were significantly associated with progression to ESRD. Conclusion: Our study demonstrated that patients with biopsy proven ATN and AIN are at high risk of developing ESRD. AIN showed higher rate of non-renal recovery at 6 month than ATN.

    Original languageEnglish
    Article numberE206
    JournalJournal of Korean medical science
    Issue number26
    Publication statusPublished - 2020 Jul 6

    Bibliographical note

    Publisher Copyright:
    © 2020 The Korean Academy of Medical Sciences.


    • Acute interstitial nephritis
    • Acute tubular necrosis
    • Fibrosis
    • Inflammation

    ASJC Scopus subject areas

    • General Medicine


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