Long-term study of the association of adipokines and glucose variability with diabetic complications

Jin Joo Cha, Hye Sook Min, Kitae Kim, Mi Jin Lee, Mi Hwa Lee, Jung Eun Kim, Hye Kyoung Song, Dae Ryong Cha, Young Sun Kang

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    Background/Aims: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. Methods: A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and vis-it-to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated. Results: Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications. Conclusions: Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.

    Original languageEnglish
    Pages (from-to)367-382
    Number of pages16
    JournalKorean Journal of Internal Medicine
    Issue number2
    Publication statusPublished - 2018 Mar

    Bibliographical note

    Publisher Copyright:
    © 2018 The Korean Association of Internal Medicine.


    • Adipokines
    • Adiponectin
    • Diabetes complications
    • Glucose variability
    • Glypicans

    ASJC Scopus subject areas

    • Internal Medicine


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