Longitudinally guided level sets for consistent tissue segmentation of neonates

Li Wang, Feng Shi, Pew Thian Yap, Weili Lin, John H. Gilmore, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Quantification of brain development as well as disease-induced pathologies in neonates often requires precise delineation of white matter, grey matter and cerebrospinal fluid. Unlike adults, tissue segmentation in neonates is significantly more challenging due to the inherently lower tissue contrast. Most existing methods take a voxel-based approach and are limited to working with images from a single time-point, even though longitudinal scans are available. We take a different approach by taking advantage of the fact that the pattern of the major sulci and gyri are already present in the neonates and generally preserved but fine-tuned during brain development. That is, the segmentation of late-time-point image can be used to guide the segmentation of neonatal image. Accordingly, we propose a novel longitudinally guided level-sets method for consistent neonatal image segmentation by combining local intensity information, atlas spatial prior, cortical thickness constraint, and longitudinal information into a variational framework. The minimization of the proposed energy functional is strictly derived from a variational principle. Validation performed on both simulated and in vivo neonatal brain images shows promising results. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)956-972
Number of pages17
JournalHuman Brain Mapping
Issue number4
Publication statusPublished - 2013 Apr


  • Level sets
  • Longitudinally guided segmentation
  • Neonate
  • Variational method

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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