Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee; Jianzhou Wang; Michael Torbenson; You Lu; Qiong Z. Liu; Shibo Li

doi:10.1016/j.cancergencyto.2009.09.005

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee, Jianzhou Wang, Michael Torbenson, You Lu, Qiong Z. Liu, Shibo Li

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.09.005
Publication status	Published - 2010 Jan 15
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cancergencyto.2009.09.005

Cite this

@article{17d43b1fb93342229ea94d773c188d0a,

title = "Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization",

abstract = "We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.",

author = "Jiyun Lee and Jianzhou Wang and Michael Torbenson and You Lu and Liu, {Qiong Z.} and Shibo Li",

year = "2010",

month = jan,

day = "15",

doi = "10.1016/j.cancergencyto.2009.09.005",

language = "English",

volume = "196",

pages = "179--183",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

AU - Lee, Jiyun

AU - Wang, Jianzhou

AU - Torbenson, Michael

AU - Lu, You

AU - Liu, Qiong Z.

AU - Li, Shibo

PY - 2010/1/15

Y1 - 2010/1/15

N2 - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

AB - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

UR - http://www.scopus.com/inward/record.url?scp=71649113569&partnerID=8YFLogxK

U2 - 10.1016/j.cancergencyto.2009.09.005

DO - 10.1016/j.cancergencyto.2009.09.005

M3 - Article

C2 - 20082856

AN - SCOPUS:71649113569

SN - 0165-4608

VL - 196

SP - 179

EP - 183

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this