Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee; Jianzhou Wang; Michael Torbenson; You Lu; Qiong Z. Liu; Shibo Li

doi:10.1016/j.cancergencyto.2009.09.005

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Jiyun Lee
, Jianzhou Wang
, Michael Torbenson
, You Lu
, Qiong Z. Liu
, Shibo Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.09.005
Publication status	Published - 2010 Jan 15
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2009.09.005

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title = "Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization",

abstract = "We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.",

author = "Jiyun Lee and Jianzhou Wang and Michael Torbenson and You Lu and Liu, \{Qiong Z.\} and Shibo Li",

year = "2010",

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doi = "10.1016/j.cancergencyto.2009.09.005",

language = "English",

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journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

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T1 - Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

AU - Lee, Jiyun

AU - Wang, Jianzhou

AU - Torbenson, Michael

AU - Lu, You

AU - Liu, Qiong Z.

AU - Li, Shibo

PY - 2010/1/15

Y1 - 2010/1/15

N2 - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

AB - We report oligo-array comparative genomic hybridization findings in a case of malignant phyllodes tumor of the breast. In addition to gains of 1q and 5p, and losses of 10p and 13q14∼q22, this tumor had also losses of two regions to which tumor suppressor genes are mapped: 1p36 (SDHB) and 17q11.2 (NF1). Both genes are associated with hereditary cancer syndromes, including gastrointestinal stromal tumors. Whether these two genes played a role in the development or progression of this phyllodes tumor of the breast with a sarcomatous stromal component warrants further investigation of similar cases.

UR - https://www.scopus.com/pages/publications/71649113569

U2 - 10.1016/j.cancergencyto.2009.09.005

DO - 10.1016/j.cancergencyto.2009.09.005

M3 - Article

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AN - SCOPUS:71649113569

SN - 0165-4608

VL - 196

SP - 179

EP - 183

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization

Abstract

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