Low-dose radiation induces drosophila innate immunity through toll pathway activation

Ki Moon Seong, Cha Soon Kim, Byung Sub Lee, Seon Young Nam, Kwang Hee Yang, Ji Young Kim, Joong Jean Park, Kyung Jin Min, Young Woo Jin

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against grampositive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalJournal of Radiation Research
Issue number2
Publication statusPublished - 2012 Mar
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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