Abstract
Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here, we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy. Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for autophagy-related diseases.
Original language | English |
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Pages (from-to) | 176-183 |
Number of pages | 8 |
Journal | Biochemical and biophysical research communications |
Volume | 526 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2020 May 21 |
Bibliographical note
Funding Information:This work was supported by Creative Research Initiatives Program (Research Center for Epigenetic Code and Diseases , 2017R1A3B1023387 ) and the Science Research Center program ( NRF-2016R1A5A1010764 ) to S.H.B.; Global PhD Fellowship Program ( NRF-2019H1A2A1073581 ) to S.A.C.; the Basic Science Research Program ( NRF-2014R1A6A3A04057910 ) and Korea University Grant ( K1925011 ) to H.K. from the National Research Foundation ( NRF ) grant funded by the Korea government.
Funding Information:
This work was supported by Creative Research Initiatives Program (Research Center for Epigenetic Code and Diseases, 2017R1A3B1023387) and the Science Research Center program (NRF-2016R1A5A1010764) to S.H.B.; Global PhD Fellowship Program (NRF-2019H1A2A1073581) to S.A.C.; the Basic Science Research Program (NRF-2014R1A6A3A04057910) and Korea University Grant (K1925011) to H.K. from the National Research Foundation (NRF) grant funded by the Korea government.
Publisher Copyright:
© 2020 Elsevier Inc.
Keywords
- Autophagy
- H3K9 demethylation
- KDM3A
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology