M-13 bacteriophage based structural color sensor for detecting antibiotics

Jong Sik Moon, Minji Park, Won Geun Kim, Chuntae Kim, Jinyoung Hwang, Daun Seol, Chang Seok Kim, Jong Ryeul Sohn, Hoeil Chung, Jin Woo Oh

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Color sensor systems that exploit the advantages of M-13 bacteriophage have been shown to be potentially useful for detection of hazardous materials. The properties of M-13 bacteriophage can be systemically modified to impart target-specific selectivity and sensitivity using the phage display technique. Here, we describe a structural color-based sensor that utilizes genetically engineered M-13 bacteriophage to discriminate different types of antibiotics. An M-13 bacteriophage based structural color matrix was fabricated using a simple pulling technique by self-assembly of M-13 bacteriophage. When exposed to organic solvent, M-13 bacteriophage bundles promptly swell and promote distinct structural color change. Color sensors composed of M-13 bacteriophage genetically engineered to possess WHW peptide motifs clearly discriminated three different types of antibiotics, which was based on the color analysis of sensor using principal component analysis. Our sensing approach based on M-13 bacteriophage could be a promising sensor technique such as an environmental monitoring system.

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalSensors and Actuators, B: Chemical
Publication statusPublished - 2017 Mar 1

Bibliographical note

Funding Information:
This research was supported by Korea Ministry of Environment as The Converging Technology Program (ARQ201403075001) and by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through Advanced Production Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affair s(MAFRA) ( 314033-02 ).

Publisher Copyright:
© 2016 Elsevier B.V.


  • Antibiotics
  • Biophotonics
  • Color sensor
  • M-13 bacteriophage
  • Self-assembly
  • Virus

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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