Macro-/micro-environment-sensitive chemosensing and biological imaging

Zhigang Yang, Jianfang Cao, Yanxia He, Jung Ho Yang, Taeyoung Kim, Xiaojun Peng, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

640 Citations (Scopus)


Environment-related parameters, including viscosity, polarity, temperature, hypoxia, and pH, play pivotal roles in controlling the physical or chemical behaviors of local molecules. In particular, in a biological environment, such factors predominantly determine the biological properties of the local environment or reflect corresponding status alterations. Abnormal changes in these factors would cause cellular malfunction or become a hallmark of the occurrence of severe diseases. Therefore, in recent years, they have increasingly attracted research interest from the fields of chemistry and biological chemistry. With the emergence of fluorescence sensing and imaging technology, several fluorescent chemosensors have been designed to respond to such parameters and to further map their distributions and variations in vitro/in vivo. In this work, we have reviewed a number of various environment-responsive chemosensors related to fluorescent recognition of viscosity, polarity, temperature, hypoxia, and pH that have been reported thus far.

Original languageEnglish
Pages (from-to)4563-4601
Number of pages39
JournalChemical Society Reviews
Issue number13
Publication statusPublished - 2014 Jul 7

ASJC Scopus subject areas

  • Chemistry(all)


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