Abstract
A combination of bi-axial machining and lamination was used to fabricate macrochanneled poly (ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds. Thermoplastic PCL/HA sheets with a thickness of 1 mm, consisting of a 40 wt% PCL polymer and 60 wt% HA particles, were bi-axially machined. The thermoplastic PCL/HA exhibited an excellent surface finish with negligible tearing of the PCL polymer and pull-out of the HA particles. The bi-axially machined sheets were laminated with a solvent to give permanent bonding between the lamina. This novel process produced three-directionally connected macrochannels in the dense PCL/HA body. The macrochanneled PCL/HA scaffold exhibited excellent ductility and reasonably high strength. In addition, good cellular responses were observed due to the osteoconductive HA particles.
| Original language | English |
|---|---|
| Pages (from-to) | 773-778 |
| Number of pages | 6 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 17 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2006 Sept |
| Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgements This work was supported by a grant from the Korea Health 21 R & D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Biomaterials
- Biomedical Engineering