Macrolide resistance and its impacts on M. pneumoniae pneumonia in children: Comparison of two recent epidemics in Korea

Jong Hyun Kim, Jee Yong Kim, Chang Hoon Yoo, Won Hee Seo, Young Yoo, Dae Jin Song, Ji Tae Choung

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Purpose: The aim of this study was to investigate the change in macrolide resistance rate in pediatric Mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant M. pneumoniae (MRMP) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in Korea. Methods: A total of 250 patients with M. pneumoniae pneumonia admitted to a single tertiary hospital were enrolled in this study. Detection of MRMP was based on specific point mutations in domain V of the 23S rRNA gene. The medical records of enrolled patients were reviewed retrospectively, and the clinical courses and laboratory data were compared. Results: The macrolide resistance rate of M. pneumoniae was 51.1% (48/94) in the 2011 epidemic, and 87.2% (136/156) in the 2015 epidemic. All MRMP isolates had the A2063G point mutation. In comparison of 2 epidemics, the mean age of patients with M. pneumoniae pneumonia was increased, and the total febrile days and febrile days after initiation of macrolides were prolonged in the 2015 epidemic. Overall severity of MRMP or macrolide-susceptible M. pneumoniae (MSMP) pneumonia over 2 epidemics was not significantly changed. However, the proportion of patients who had a fever lasting more than 72 hours after initiation of macrolides and who received corticosteroid treatment were higher in MRMP pneumonia during 2 epidemics. Conclusions: The macrolide resistance rate of M. pneumoniae has risen rapidly over 2 recent, consecutive epidemics, and this has been associated with a prolonged clinical course and increased use of corticosteroids to treat pediatric M. pneumoniae pneumonia.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalAllergy, Asthma and Immunology Research
Issue number4
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Korean Academy of Asthma, Allergy and Clinical Immunology.


  • Drug resistance
  • Macrolides
  • Mycoplasma pneumoniae

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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