@inproceedings{170311fad2b94c76873014be937d597e,
title = "Macromolecule delivery into hard-to-transefct primary cells via hydrodynamic cell deformation",
abstract = "We present a versatile microfluidic intracellular delivery platform that can deliver large nanomaterials effectively into diverse primary cells via hydrodynamic cell deformation in a novel T-junction microchannel with a cavity. Briefly, a syringe pump was used to inject a cell suspension with cargo of interest into a microchannel at a moderate Re to induce the development of inertial vortices. The recirculating flows deformed the cells, generating transient nanopores on the cellular membrane. This intrinsically cell deformation enables highly effective transport of different nanomaterials into various cell types including difficult-to-transfect primary cells, in a high-throughput and minimally invasive manner.",
keywords = "Cell Transfection, Cell-based Therapy, Gene Delivery, Hydroporator, Intracellular delivery",
author = "Jeongsoo Hur and Aram Chung",
note = "Funding Information: This work is supported by the Samsung Research Funding and Incubation Center for Future Technology (Grant No. SRFC-IT1802-03). Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "817--818",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}