Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing

Alexander H. Mo; Preston B. Landon; Karla Santacruz Gomez; Heemin Kang; Joon Lee; Chen Zhang; Woraphong Janetanakit; Vrinda Sant; Tianyu Lu; David A. Colburn; Siddhartha Akkiraju; Samuel Dossou; Yue Cao; Kuo Fen Lee; Shyni Varghese; Gennadi Glinsky; Ratnesh Lal

doi:10.1039/c6nr02445a

Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing

Alexander H. Mo, Preston B. Landon, Karla Santacruz Gomez, Heemin Kang, Joon Lee, Chen Zhang, Woraphong Janetanakit, Vrinda Sant, Tianyu Lu, David A. Colburn, Siddhartha Akkiraju, Samuel Dossou, Yue Cao, Kuo Fen Lee, Shyni Varghese, Gennadi Glinsky, Ratnesh Lal

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Original language	English
Pages (from-to)	11840-11850
Number of pages	11
Journal	Nanoscale
Volume	8
Issue number	23
DOIs	https://doi.org/10.1039/c6nr02445a
Publication status	Published - 2016 Jun 21
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)

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Mo, A. H., Landon, P. B., Gomez, K. S., Kang, H., Lee, J., Zhang, C., Janetanakit, W., Sant, V., Lu, T., Colburn, D. A., Akkiraju, S., Dossou, S., Cao, Y., Lee, K. F., Varghese, S., Glinsky, G., & Lal, R. (2016). Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing. Nanoscale, 8(23), 11840-11850. https://doi.org/10.1039/c6nr02445a

@article{656a61928a854f7692cb503891a14304,

title = "Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing",

abstract = "Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.",

author = "Mo, {Alexander H.} and Landon, {Preston B.} and Gomez, {Karla Santacruz} and Heemin Kang and Joon Lee and Chen Zhang and Woraphong Janetanakit and Vrinda Sant and Tianyu Lu and Colburn, {David A.} and Siddhartha Akkiraju and Samuel Dossou and Yue Cao and Lee, {Kuo Fen} and Shyni Varghese and Gennadi Glinsky and Ratnesh Lal",

note = "Funding Information: We would like to thank Professor Jan Talbot for access to the DLS instrument. We thank the NANO3 staff for access to the SEM and related support. We thank Issac Liu and Professor Sungho Jin for access to the VSM. Also thanks to UCSD Electron Microscope Facility staff Timothy Meerloo and Ying Jones for access to the TEM and related support. Thanks to Matthew Rozin for help with the UV-vis-IR spectrometer. Finally thanks to Professor Seth Cohen for access to the FTIR instrument. This work was funded by UCSD startup funds and NIH grants R01DA024871 and R01DA025296 to R. L. Post-doctoral Fellowship (237085) provided by Consejo Nacional de Ciencia y Tecnoloǵa (CONACyT) to K. S.-G. Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

month = jun,

day = "21",

doi = "10.1039/c6nr02445a",

language = "English",

volume = "8",

pages = "11840--11850",

journal = "Nanoscale",

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T1 - Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing

AU - Mo, Alexander H.

AU - Landon, Preston B.

AU - Gomez, Karla Santacruz

AU - Kang, Heemin

AU - Lee, Joon

AU - Zhang, Chen

AU - Janetanakit, Woraphong

AU - Sant, Vrinda

AU - Lu, Tianyu

AU - Colburn, David A.

AU - Akkiraju, Siddhartha

AU - Dossou, Samuel

AU - Cao, Yue

AU - Lee, Kuo Fen

AU - Varghese, Shyni

AU - Glinsky, Gennadi

AU - Lal, Ratnesh

N1 - Funding Information: We would like to thank Professor Jan Talbot for access to the DLS instrument. We thank the NANO3 staff for access to the SEM and related support. We thank Issac Liu and Professor Sungho Jin for access to the VSM. Also thanks to UCSD Electron Microscope Facility staff Timothy Meerloo and Ying Jones for access to the TEM and related support. Thanks to Matthew Rozin for help with the UV-vis-IR spectrometer. Finally thanks to Professor Seth Cohen for access to the FTIR instrument. This work was funded by UCSD startup funds and NIH grants R01DA024871 and R01DA025296 to R. L. Post-doctoral Fellowship (237085) provided by Consejo Nacional de Ciencia y Tecnoloǵa (CONACyT) to K. S.-G. Publisher Copyright: © 2016 The Royal Society of Chemistry.

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

AB - Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

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U2 - 10.1039/c6nr02445a

DO - 10.1039/c6nr02445a

M3 - Article

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AN - SCOPUS:84974622682

SN - 2040-3364

VL - 8

SP - 11840

EP - 11850

JO - Nanoscale

JF - Nanoscale

IS - 23

ER -

Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing

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