Major genetic components underlying alcoholism in Korean population

Dai Jin Kim; Ihn Geun Choi; Byung Lae Park; Boung Chul Lee; Byung Joo Ham; Sujung Yoon; Joon Seol Bae; Hyun Sub Cheong; Hyoung Doo Shin

doi:10.1093/hmg/ddm357

Major genetic components underlying alcoholism in Korean population

Dai Jin Kim
, Ihn Geun Choi^*
, Byung Lae Park
, Boung Chul Lee
, Byung Joo Ham
, Sujung Yoon
, Joon Seol Bae
, Hyun Sub Cheong
, Hyoung Doo Shin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B (His47Arg) and ALDH2 (Glu487Lys) have dramatic effects on the rate of metabolizing alcohol and acetaldehyde, respectively. The protective allele of ADH1B (ADH1B*47His) encodes for a rapid ethanol-metabolizing enzyme, and the susceptible allele of the ALDH2 (ALDH2*487Lys) is strongly associated with decreased rate of metabolizing acetaldehyde. However, the combined genetic effects of both functional polymorphisms have not been clarified. The combined analysis of two polymorphisms among a Korean population (n = 1,032) revealed dramatic genetic effects on the risk of alcoholism. Individuals bearing susceptible alleles at both loci have 91 times greater risk for alcoholism [odds ratio (OR) = 91.43, P = 1.4 × 10^-32] and individuals bearing one susceptible and one protective allele at either loci have 11 times greater risk (OR = 11.40, P = 3.5 × 10^-15) compared with subjects who have both protective alleles. The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.

Original language	English
Pages (from-to)	854-858
Number of pages	5
Journal	Human Molecular Genetics
Volume	17
Issue number	6
DOIs	https://doi.org/10.1093/hmg/ddm357
Publication status	Published - 2008 Mar 15
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a grant from the National Research Lab Program as part of the National Research and Development Program of the Ministry of Commerce, Industry and Energy of Korea (M1-0302-00-0073). This study was also partly supported by a grant from Biomedical Brain Research Center (A040042) and a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare (03-PJ10-PG13-GD01-0002) funded by the Ministry of Health & Welfare, Republic of Korea.

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/hmg/ddm357

Cite this

@article{33539a8b8e5f4d969abf452f21891180,

title = "Major genetic components underlying alcoholism in Korean population",

abstract = "Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B (His47Arg) and ALDH2 (Glu487Lys) have dramatic effects on the rate of metabolizing alcohol and acetaldehyde, respectively. The protective allele of ADH1B (ADH1B*47His) encodes for a rapid ethanol-metabolizing enzyme, and the susceptible allele of the ALDH2 (ALDH2*487Lys) is strongly associated with decreased rate of metabolizing acetaldehyde. However, the combined genetic effects of both functional polymorphisms have not been clarified. The combined analysis of two polymorphisms among a Korean population (n = 1,032) revealed dramatic genetic effects on the risk of alcoholism. Individuals bearing susceptible alleles at both loci have 91 times greater risk for alcoholism [odds ratio (OR) = 91.43, P = 1.4 × 10-32] and individuals bearing one susceptible and one protective allele at either loci have 11 times greater risk (OR = 11.40, P = 3.5 × 10-15) compared with subjects who have both protective alleles. The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5\% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.",

author = "Kim, \{Dai Jin\} and Choi, \{Ihn Geun\} and Park, \{Byung Lae\} and Lee, \{Boung Chul\} and Ham, \{Byung Joo\} and Sujung Yoon and Bae, \{Joon Seol\} and Cheong, \{Hyun Sub\} and Shin, \{Hyoung Doo\}",

note = "Funding Information: This work was supported by a grant from the National Research Lab Program as part of the National Research and Development Program of the Ministry of Commerce, Industry and Energy of Korea (M1-0302-00-0073). This study was also partly supported by a grant from Biomedical Brain Research Center (A040042) and a grant of the Korea Health 21 R\&D Project, Ministry of Health \& Welfare (03-PJ10-PG13-GD01-0002) funded by the Ministry of Health \& Welfare, Republic of Korea.",

year = "2008",

month = mar,

day = "15",

doi = "10.1093/hmg/ddm357",

language = "English",

volume = "17",

pages = "854--858",

journal = "Human Molecular Genetics",

issn = "0964-6906",

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T1 - Major genetic components underlying alcoholism in Korean population

AU - Kim, Dai Jin

AU - Choi, Ihn Geun

AU - Park, Byung Lae

AU - Lee, Boung Chul

AU - Ham, Byung Joo

AU - Yoon, Sujung

AU - Bae, Joon Seol

AU - Cheong, Hyun Sub

AU - Shin, Hyoung Doo

N1 - Funding Information: This work was supported by a grant from the National Research Lab Program as part of the National Research and Development Program of the Ministry of Commerce, Industry and Energy of Korea (M1-0302-00-0073). This study was also partly supported by a grant from Biomedical Brain Research Center (A040042) and a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare (03-PJ10-PG13-GD01-0002) funded by the Ministry of Health & Welfare, Republic of Korea.

PY - 2008/3/15

Y1 - 2008/3/15

N2 - Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B (His47Arg) and ALDH2 (Glu487Lys) have dramatic effects on the rate of metabolizing alcohol and acetaldehyde, respectively. The protective allele of ADH1B (ADH1B*47His) encodes for a rapid ethanol-metabolizing enzyme, and the susceptible allele of the ALDH2 (ALDH2*487Lys) is strongly associated with decreased rate of metabolizing acetaldehyde. However, the combined genetic effects of both functional polymorphisms have not been clarified. The combined analysis of two polymorphisms among a Korean population (n = 1,032) revealed dramatic genetic effects on the risk of alcoholism. Individuals bearing susceptible alleles at both loci have 91 times greater risk for alcoholism [odds ratio (OR) = 91.43, P = 1.4 × 10-32] and individuals bearing one susceptible and one protective allele at either loci have 11 times greater risk (OR = 11.40, P = 3.5 × 10-15) compared with subjects who have both protective alleles. The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.

AB - Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. Alcohol dehydrogenase (ADH) converts alcohol to acetaldehyde, and aldehyde dehydrogenase (ALDH) converts acetaldehyde to acetate. The well-known genetic polymorphisms in ADH1B (His47Arg) and ALDH2 (Glu487Lys) have dramatic effects on the rate of metabolizing alcohol and acetaldehyde, respectively. The protective allele of ADH1B (ADH1B*47His) encodes for a rapid ethanol-metabolizing enzyme, and the susceptible allele of the ALDH2 (ALDH2*487Lys) is strongly associated with decreased rate of metabolizing acetaldehyde. However, the combined genetic effects of both functional polymorphisms have not been clarified. The combined analysis of two polymorphisms among a Korean population (n = 1,032) revealed dramatic genetic effects on the risk of alcoholism. Individuals bearing susceptible alleles at both loci have 91 times greater risk for alcoholism [odds ratio (OR) = 91.43, P = 1.4 × 10-32] and individuals bearing one susceptible and one protective allele at either loci have 11 times greater risk (OR = 11.40, P = 3.5 × 10-15) compared with subjects who have both protective alleles. The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.

UR - https://www.scopus.com/pages/publications/40549085694

U2 - 10.1093/hmg/ddm357

DO - 10.1093/hmg/ddm357

M3 - Article

C2 - 18056758

AN - SCOPUS:40549085694

SN - 0964-6906

VL - 17

SP - 854

EP - 858

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 6

ER -

Major genetic components underlying alcoholism in Korean population

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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