Management of chronic depressive patients with residual symptoms

Changsu Han, Tzung Lieh Yeh, Masaki Kato, Soichiro Sato, Chia Ming Chang, Chi Un Pae

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Various clinical issues are involved in the appropriate diagnosis and proper treatment interventions for patients with major depressive disorder (MDD). Despite a number of diverse antidepressants for treating MDD now, response and remission rates following adequate trials of antidepressant intervention are still not satisfactory. Furthermore, a significant proportion of MDD patients have residual symptoms, which are associated with increased relapse and recurrence of MDD, leading to negative impacts on the clinical course and outcomes of MDD. Timely and appropriate decision-making regarding the proper management of such cases is required in our routine daily practice. These issues are illustrated and also framed by one MDD case with a complicated clinical course. This review paper may give physicians clinical insight into how we can effectively and properly evaluate and manage such patients in clinical practice.

Original languageEnglish
Pages (from-to)S53-S57
JournalCNS Drugs
Volume27
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2013 May
Externally publishedYes

Bibliographical note

Funding Information:
Conflict of interest Dr Han has received research grants from GlaxoSmithKline Korea, Eisai Korea, Korea Otsuka International Asia and Arab, Hanlim Pharmaceutical, Janssen Pharmaceuticals Korea, Eli Lilly and Company Korea, Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea, Korean Research Foundation, and Otsuka Korea; and has received honoraria from GlaxoSmithKline Korea, Lundbeck Korea, Astra-Zeneca Korea, Janssen Pharmaceuticals Korea, Eisai Korea, Abott Korea, Eli Lilly and Company Korea, Norvatis Korea and Otsuka Korea. Dr Pae has received research grants from Eisai Korea, Janssen Pharmaceuticals Korea, Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea, and Korean Research Foundation; and has received honoraria from Pfizer Korea and Otsuka Korea. Drs Yeh, Kato, Sato and Chang have received honoraria from Korea Otsuka International Asia and Arab.

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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