Management of chronic depressive patients with residual symptoms

Changsu Han, Tzung Lieh Yeh, Masaki Kato, Soichiro Sato, Chia Ming Chang, Chi Un Pae

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Various clinical issues are involved in the appropriate diagnosis and proper treatment interventions for patients with major depressive disorder (MDD). Despite a number of diverse antidepressants for treating MDD now, response and remission rates following adequate trials of antidepressant intervention are still not satisfactory. Furthermore, a significant proportion of MDD patients have residual symptoms, which are associated with increased relapse and recurrence of MDD, leading to negative impacts on the clinical course and outcomes of MDD. Timely and appropriate decision-making regarding the proper management of such cases is required in our routine daily practice. These issues are illustrated and also framed by one MDD case with a complicated clinical course. This review paper may give physicians clinical insight into how we can effectively and properly evaluate and manage such patients in clinical practice.

Original languageEnglish
Pages (from-to)S53-S57
JournalCNS Drugs
Issue numberSUPPL.1
Publication statusPublished - 2013 May
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Management of chronic depressive patients with residual symptoms'. Together they form a unique fingerprint.

Cite this