Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients

Seung Gul Kang; Jung Eun Choi; Hyonggin An; Young Min Park; Heon Jeong Lee; Changsu Han; Yong Ku Kim; Seung Hyun Kim; Sung Nam Cho; Sook Haeng Joe; In Kwa Jung; Leen Kim; Min Soo Lee

doi:10.1016/j.pnpbp.2008.08.013

Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients

Seung Gul Kang, Jung Eun Choi, Hyonggin An, Young Min Park, Heon Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Sook Haeng Joe, In Kwa Jung, Leen Kim, Min Soo Lee

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.

Original language	English
Pages (from-to)	1844-1847
Number of pages	4
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	32
Issue number	8
DOIs	https://doi.org/10.1016/j.pnpbp.2008.08.013
Publication status	Published - 2008 Dec 12

Bibliographical note

Funding Information:
This study was supported in part by a grant from the Korean Health 21 R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (no. 03-PJ10-PG13-GD01-0002).

Keywords

Abnormal involuntary movements
Manganese superoxide dismutase
Polymorphism
Schizophrenia
Tardive dyskinesia

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2008.08.013

Cite this

Kang, S. G., Choi, J. E., An, H., Park, Y. M., Lee, H. J., Han, C., Kim, Y. K., Kim, S. H., Cho, S. N., Joe, S. H., Jung, I. K., Kim, L., & Lee, M. S. (2008). Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(8), 1844-1847. https://doi.org/10.1016/j.pnpbp.2008.08.013

Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. / Kang, Seung Gul; Choi, Jung Eun; An, Hyonggin et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 8, 12.12.2008, p. 1844-1847.

Research output: Contribution to journal › Article › peer-review

Kang, SG, Choi, JE, An, H, Park, YM, Lee, HJ, Han, C, Kim, YK, Kim, SH, Cho, SN, Joe, SH, Jung, IK, Kim, L & Lee, MS 2008, 'Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 8, pp. 1844-1847. https://doi.org/10.1016/j.pnpbp.2008.08.013

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title = "Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients",

abstract = "Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.",

keywords = "Abnormal involuntary movements, Manganese superoxide dismutase, Polymorphism, Schizophrenia, Tardive dyskinesia",

author = "Kang, {Seung Gul} and Choi, {Jung Eun} and Hyonggin An and Park, {Young Min} and Lee, {Heon Jeong} and Changsu Han and Kim, {Yong Ku} and Kim, {Seung Hyun} and Cho, {Sung Nam} and Joe, {Sook Haeng} and Jung, {In Kwa} and Leen Kim and Lee, {Min Soo}",

note = "Funding Information: This study was supported in part by a grant from the Korean Health 21 R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (no. 03-PJ10-PG13-GD01-0002).",

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doi = "10.1016/j.pnpbp.2008.08.013",

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AU - Kang, Seung Gul

AU - Choi, Jung Eun

AU - An, Hyonggin

AU - Park, Young Min

AU - Lee, Heon Jeong

AU - Han, Changsu

AU - Kim, Yong Ku

AU - Kim, Seung Hyun

AU - Cho, Sung Nam

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Kim, Leen

AU - Lee, Min Soo

N1 - Funding Information: This study was supported in part by a grant from the Korean Health 21 R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (no. 03-PJ10-PG13-GD01-0002).

PY - 2008/12/12

Y1 - 2008/12/12

N2 - Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.

AB - Objective: This study examined whether the manganese superoxide dismutase (MnSOD) gene Ala-9Val single-nucleotide polymorphism (SNP) is associated with neuroleptic-induced tardive dyskinesia (TD) and the severity of the abnormal involuntary movements in Korean schizophrenic patients. Method: We investigated whether the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients with (n = 83) and without (n = 126) TD who were matched for exposure to antipsychotics and other relevant variables. Results: Logistic regression analysis revealed that being older (p = 0.026) was a risk factor for TD, but that there was no significant association between MnSOD gene and TD. Abnormal involuntary movements were more severe in carriers of the Ala allele than in noncarriers (p = 0.044). Conclusion: These findings do not support that the MnSOD gene Ala-9Val SNP is associated with TD in Korean schizophrenic patients. However, this polymorphism might be related to the severity of abnormal involuntary movements in this population.

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Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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