Mapping the surface charge distribution of amyloid fibril

Gyudo Lee; Wonseok Lee; Hyungbeen Lee; Sang Woo Lee; Dae Sung Yoon; Kilho Eom; Taeyun Kwon

doi:10.1063/1.4739494

Mapping the surface charge distribution of amyloid fibril

Gyudo Lee, Wonseok Lee, Hyungbeen Lee, Sang Woo Lee, Dae Sung Yoon, Kilho Eom, Taeyun Kwon

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.

Original language	English
Article number	043703
Journal	Applied Physics Letters
Volume	101
Issue number	4
DOIs	https://doi.org/10.1063/1.4739494
Publication status	Published - 2012 Jul 23
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) of Korea under Grant Nos. NRF-2010-0009428 and NRF-2012-008616.

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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abstract = "It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.",

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AU - Lee, Gyudo

AU - Lee, Wonseok

AU - Lee, Hyungbeen

AU - Woo Lee, Sang

AU - Sung Yoon, Dae

AU - Eom, Kilho

AU - Kwon, Taeyun

N1 - Funding Information: This work was supported by the National Research Foundation (NRF) of Korea under Grant Nos. NRF-2010-0009428 and NRF-2012-008616.

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Y1 - 2012/7/23

N2 - It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.

AB - It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.

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Mapping the surface charge distribution of amyloid fibril

Abstract

Bibliographical note

ASJC Scopus subject areas

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