Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

Hyojeong Kim; Taek Joon Yoon; Sung Won Lee; Daesun Yun; Ji Yeon Kim; Kwang Soon Shin; Se Ho Park; Seokmann Hong

doi:10.1080/19768354.2011.630411

Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

Hyojeong Kim, Taek Joon Yoon, Sung Won Lee, Daesun Yun, Ji Yeon Kim, Kwang Soon Shin, Se Ho Park, Seokmann Hong

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

Original language	English
Pages (from-to)	215-223
Number of pages	9
Journal	Animal Cells and Systems
Volume	16
Issue number	3
DOIs	https://doi.org/10.1080/19768354.2011.630411
Publication status	Published - 2012 Jun

Bibliographical note

Funding Information:
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (#0820270).

Keywords

dendritic cells
heat-killed tumor cells
interleukin 12

ASJC Scopus subject areas

Animal Science and Zoology
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/19768354.2011.630411

Cite this

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title = "Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells",

abstract = "Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.",

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author = "Hyojeong Kim and Yoon, {Taek Joon} and Lee, {Sung Won} and Daesun Yun and Kim, {Ji Yeon} and Shin, {Kwang Soon} and Park, {Se Ho} and Seokmann Hong",

note = "Funding Information: This study was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (#0820270).",

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AU - Kim, Ji Yeon

AU - Shin, Kwang Soon

AU - Park, Se Ho

AU - Hong, Seokmann

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Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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