Mature B cells and mesenchymal stem cells control emergency myelopoiesis

Vivian Y. Lim, Xing Feng, Runfeng Miao, Sandra Zehentmeier, Nathan Ewing-Crystal, Moonyoung Lee, Alexei V. Tumanov, Ji Eun Oh, Akiko Iwasaki, Andrew Wang, Jungmin Choi, João P. Pereira

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How blood cell production switches from homeostasis to emergency myelopoiesis is incompletely understood. Here, we show that lymphotoxin-β receptor (LTβR) signaling in combination with TNF and IL-1 receptor signaling in bone marrow mesenchymal stem cells (MSCs) down-regulates Il7 expression to shut down lymphopoiesis during systemic inflammation. LTβR signaling in MSCs also promoted CCL2 production during systemic inflammation. Pharmacological or genetic blocking of LTβR signaling in MSCs partially enabled lymphopoiesis and reduced monocyte numbers in the spleen during systemic inflammation, which correlated with reduced survival during systemic bacterial and viral infections. Interestingly, lymphotoxin-α1β2 delivered by B-lineage cells, and specifically by mature B cells, contributed to promote Il7 down-regulation and reduce MSC lymphopoietic activity. Our studies revealed an unexpected role of LTβR signaling in MSCs and identified recirculating mature B cells as an important regulator of emergency myelopoiesis.

Original languageEnglish
Article numbere202301924
JournalLife Science Alliance
Issue number4
Publication statusPublished - 2023 Apr

Bibliographical note

Publisher Copyright:
© 2023 Lim et al.

ASJC Scopus subject areas

  • Ecology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Plant Science
  • Health, Toxicology and Mutagenesis


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